Imidazolium-tagged glycan probes for non-covalent labeling of live cells

David Benito-Alifonso, Shirley Tremell, Joanna C Sadler, Monica Berry, M Carmen Galan

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
280 Downloads (Pure)

Abstract

Selective, bioorthogonal and fast labeling of glycoconjugates in living cells is a major challenge for synthetic and cellular biology. Here we report the use imidazolium tagged-mannosamine derivative (ITag-Man) for the non-covalent, rapid and site-specific labeling of sialic acid containing glycoproteins using commercial N-nitrilotriacetate fluorescent reagents in a range of cell lines.

Original languageEnglish
Pages (from-to)4906-4909
Number of pages4
JournalChemical Communications
Volume52
Issue number27
DOIs
Publication statusPublished - 7 Apr 2016

Structured keywords

  • Bristol BioDesign Institute

Keywords

  • SYNTHETIC BIOLOGY

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