Immediate hypothermia reduces cardiac troponin I following hypoxic-ischemic encephalopathy in newborn pigs

X Liu, JR Tooley, EM Loeberg, M-S Suleiman, M Thoresen

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition following lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia after birth is neuroprotective in infants with HIE. However, it is not known whether hypothermia (HT) is also cardioprotective. Four newborn pigs were used in the pilot study and a further 18 newborn pigs (randomly assigned to 72h-normothermia (NT) or 24h-HT followed by 48h-NT) were subjected to global HIE insults. Serum cTnI was measured prior to and post the HIE insult. Blood pressure, inotropic support, blood gases and heart rate (HR) were recorded throughout. Cardiac pathology was assessed from histological sections. Cooling reduced serum cTnI levels significantly in HT pigs by 6h (NT, 1.36±0.67; HT 0.34±0.23 ng/ml, p=0.0009). After rewarming, from 24 to 30h post insult, HR and cTnI increased in the HT group; from HR[24h]=117±22 to HR[30h]=218±32 beats/minute (p=0.0002) and from cTnI[24h]=0.23±0.12 to cTnI[30h]=0.65±0.53ng/ml, (p=0.05). There were fewer ischemic lesions on cardiac examination (37%) in the HT group compared to the NT group (70%). Hypothermia (24h) pigs did not have the post-insult cTnI increase seen in NT treated pigs. There was a trend that HT improved cardiac pathology in this 3-day survival model.
Translated title of the contributionImmediate hypothermia reduces cardiac troponin I following hypoxic-ischemic encephalopathy in newborn pigs
Original languageEnglish
Article numbere-pub 17 June 2011
JournalPediatric Research
Volume70
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Dive into the research topics of 'Immediate hypothermia reduces cardiac troponin I following hypoxic-ischemic encephalopathy in newborn pigs'. Together they form a unique fingerprint.

Cite this