Immunodeficiency, HIV viremia, and incident anal cancer among people with HIV in South Africa

Nathalie V Fernández Villalobos; Yann Ruffieux; Chido Chinogurei; Andreas D Haas; Nicola Low; Matthias Egger; Jenni Noble; Naomi Folb; Gary Maartens; Eliane Rohner

doi:10.1093/ofid/ofaf693

Immunodeficiency, HIV viremia, and incident anal cancer among people with HIV in South Africa

Nathalie V Fernández Villalobos, Yann Ruffieux^*, Chido Chinogurei, Andreas D Haas, Nicola Low, Matthias Egger, Jenni Noble, Naomi Folb, Gary Maartens, Eliane Rohner^*

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Among 130,992 people with HIV (PWH) in South Africa, 60 anal cancers were diagnosed. Lower CD4 counts and higher HIV RNA viral loads were associated with an increased anal cancer risk. Maintaining high CD4 counts and achieving viral suppression may contribute to anal cancer prevention among PWH in South Africa.

Original language	English
Article number	ofaf693
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	12
Issue number	12
Early online date	12 Nov 2025
DOIs	https://doi.org/10.1093/ofid/ofaf693
Publication status	Published - 1 Dec 2025

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© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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SDG 3 Good Health and Well-being

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title = "Immunodeficiency, HIV viremia, and incident anal cancer among people with HIV in South Africa",

abstract = "Among 130,992 people with HIV (PWH) in South Africa, 60 anal cancers were diagnosed. Lower CD4 counts and higher HIV RNA viral loads were associated with an increased anal cancer risk. Maintaining high CD4 counts and achieving viral suppression may contribute to anal cancer prevention among PWH in South Africa.",

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AU - Fernández Villalobos, Nathalie V

AU - Ruffieux, Yann

AU - Chinogurei, Chido

AU - Haas, Andreas D

AU - Low, Nicola

AU - Egger, Matthias

AU - Noble, Jenni

AU - Folb, Naomi

AU - Maartens, Gary

AU - Rohner, Eliane

PY - 2025/12/1

Y1 - 2025/12/1

N2 - Among 130,992 people with HIV (PWH) in South Africa, 60 anal cancers were diagnosed. Lower CD4 counts and higher HIV RNA viral loads were associated with an increased anal cancer risk. Maintaining high CD4 counts and achieving viral suppression may contribute to anal cancer prevention among PWH in South Africa.

AB - Among 130,992 people with HIV (PWH) in South Africa, 60 anal cancers were diagnosed. Lower CD4 counts and higher HIV RNA viral loads were associated with an increased anal cancer risk. Maintaining high CD4 counts and achieving viral suppression may contribute to anal cancer prevention among PWH in South Africa.

U2 - 10.1093/ofid/ofaf693

DO - 10.1093/ofid/ofaf693

M3 - Article (Academic Journal)

C2 - 41311919

SN - 2328-8957

VL - 12

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 12

M1 - ofaf693

ER -

Immunodeficiency, HIV viremia, and incident anal cancer among people with HIV in South Africa

Abstract

Bibliographical note

UN SDGs

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