Immunomodulation by ultraviolet light: Clinical studies and biological effects

Derwood H Pamphilon, AA Alnaqdy, Timothy B Wallington

    Research output: Contribution to journalArticle (Academic Journal)peer-review

    60 Citations (Scopus)

    Abstract

    The interest f immunologists in ultraviolet (UV) irradiation stems from observations made in vitro and in vivo. In vitro, UV irradiation inhibits mitogen and mixed lymphocyte culture (MLC) responses and in vivo, it can induce cutaneous anergy, apparently via suppressor cells and serum factors. At present much interest is focused on the possible use of UV irradiation to permit transfusion without allosensitization and transplantation without either rejection or graft-versus-host disease (GVHD). Here, Derwood Pamphilon and colleagues discuss the current uses and potential of UV irradiation in transfusion and transplantation and relate these to experimental evidence on its effects at the cellular level.
    Translated title of the contributionImmunomodulation by ultraviolet light: Clinical studies and biological effects
    Original languageEnglish
    Pages (from-to)119-123
    Number of pages4
    JournalImmunology Today
    Volume12
    Issue number4
    DOIs
    Publication statusPublished - Apr 1991

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