Immunomodulatory drugs and their application to the management of canine immune-mediated disease

N. T. Whitley, M. J. Day

Research output: Contribution to journalReview article (Academic Journal)peer-review

48 Citations (Scopus)

Abstract

This review summarises the current understanding of immune response and T cell subsets in the context of development of autoimmunity in the dog. Mode of action and rational usage in immune-mediated disease in the dog are discussed for the following drugs: glucocorticoids, azathioprine, cyclophosphamide, ciclosporin, tacrolimus, human intravenous immunoglobulin, vincristine, danazol, leflunomide, mycophenolate mofetil and liposome-encapsulated clodronate. Disease mechanisms are discussed and published evidence for drug efficacy is scrutinised for five important immune-mediated diseases: immune-mediated haemolytic anaemia, immune-mediated thrombocytopenia, myasthenia gravis, glomerulonephritis and inflammatory bowel disease. Future strategies for more refined manipulation of adverse immune responses are presented.

Original languageEnglish
Pages (from-to)70-85
Number of pages16
JournalJournal of Small Animal Practice
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2011

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