Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial

Andrew Howman, Tracey L Chapman, Maria M Langdon, Caroline Ferguson, Dwomoa Adu, John Feehally, Gillian J Gaskin, David R W Jayne, Donal O'Donoghue, Michael Boulton-Jones, Peter W Mathieson

Research output: Contribution to journalArticle (Academic Journal)peer-review

116 Citations (Scopus)

Abstract

Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves renal function in patients with idiopathic membranous nephropathy with declining renal function.
Original languageEnglish
Pages (from-to)744-751
Number of pages8
JournalLancet
Volume381
Issue number9868
DOIs
Publication statusPublished - 2 Mar 2013

Bibliographical note

Copyright © 2013 Elsevier Ltd. All rights reserved.

Keywords

  • Drug Administration Schedule
  • Cyclosporine
  • Chlorambucil
  • Humans
  • Glomerulonephritis, Membranous
  • Immunosuppressive Agents
  • Great Britain
  • Drug Therapy, Combination
  • Glomerular Filtration Rate
  • Prednisolone
  • Kidney
  • Middle Aged
  • Survival Analysis

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