Impact of low iodine diets on ablation success in differentiated thyroid cancer: A mixed-methods systematic review and meta-analysis

Georgia Herbert*, Clare England, Rachel Perry, Alex Whitmarsh, Theresa Moore, Aidan Searle, Sneha Chotaliya, Andy Ness, Matthew Beasley, Charlotte Atkinson

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)
64 Downloads (Pure)

Abstract

Background
Debate remains regarding whether to recommend a low iodine diet (LID) before radioactive-iodine treatment and its duration and stringency. This mixed-methods review aimed to determine if iodine status affects treatment success, the most effective diet to reduce iodine status, and how LID impacts wellbeing.

Methods
Five electronic databases were searched until February 2021. An effectiveness synthesis (quantitative studies) and views synthesis (qualitative, survey, and experience-based evidence) were conducted individually and then integrated. Quality assessment was undertaken.

Results
Fifty-six quantitative and three qualitative studies were identified. There was greater ablation success for those with an iodine status of
Conclusions
Although a LID of 1–2 weeks reduces iodine status, it remains unclear whether iodine status affects treatment success as only a few low-quality studies have examined this. LIDs are challenging for patients. Higher-quality studies are needed to confirm whether a LID is necessary.
Original languageEnglish
Pages (from-to)702-729
Number of pages28
JournalClinical Endocrinology
Volume97
Issue number6
Early online date28 Apr 2022
DOIs
Publication statusPublished - 1 Nov 2022

Bibliographical note

Funding Information:
We would like to thank Dr Katy Sutcliffe from the EPPI centre at UCL for her methodological support. This study was funded by the Bristol City Centre Hospital Charity Above & Beyond. The views expressed are those of the authors and not necessarily those of the charity. In addition, this study was supported by the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust, and the University of Bristol. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.

Funding Information:
We would like to thank Dr Katy Sutcliffe from the EPPI centre at UCL for her methodological support. This study was funded by the Bristol City Centre Hospital Charity Above & Beyond. The views expressed are those of the authors and not necessarily those of the charity. In addition, this study was supported by the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust, and the University of Bristol. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.

Publisher Copyright:
© 2022 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.

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