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Abstract
Introduction
Tobacco is the world’s leading preventable cause of disease and death. People with depression are twice as likely to smoke and are less responsive to standard tobacco treatments as compared to the general population. A Cochrane systematic review of randomised controlled trials of smoking cessation treatment for smokers with current or historical depression found that adding mood management to usual smoking treatment improved quit rates. However, the review did not examine if variation in intervention delivery or intervention functions impacted on treatment effectiveness.
With the aim of providing information to develop tailored approaches to treating smoking for people with current depression we will add-on to the Cochrane review in three ways: 1) Use the Template for Intervention Description and Replication checklist to determine if variations in mood management delivery impact on intervention effectiveness, 2) Use the Taxonomy of Behaviour Change Techniques for smoking cessation to examine which behaviour change functions are most effective for smoking cessation in people with current depression, 3) Examine the difference in change in depression scores between intervention and control arms.
Methods and Analysis
We will include randomised controlled trials of smokers with current depression as identified by the previous Cochrane review and the in-progress update of the Cochrane review. We will use meta*regression to examine 1) if variations in delivery of mood management impact on smoking cessation intervention effectiveness, 2) determine which behaviour change functions are most effective for smoking cessation and 3) use meta-analysis of the difference in change in depression scores between treatment arms from baseline to follow-up to determine if offering smoking cessation treatment causes psychological harm.
Ethics and Dissemination
Ethical approval is not required for this study. We will disseminate the findings of this work at conferences, and to relevant patient panels.
Registration details
PROSPERO ID: CRD42017070741
Tobacco is the world’s leading preventable cause of disease and death. People with depression are twice as likely to smoke and are less responsive to standard tobacco treatments as compared to the general population. A Cochrane systematic review of randomised controlled trials of smoking cessation treatment for smokers with current or historical depression found that adding mood management to usual smoking treatment improved quit rates. However, the review did not examine if variation in intervention delivery or intervention functions impacted on treatment effectiveness.
With the aim of providing information to develop tailored approaches to treating smoking for people with current depression we will add-on to the Cochrane review in three ways: 1) Use the Template for Intervention Description and Replication checklist to determine if variations in mood management delivery impact on intervention effectiveness, 2) Use the Taxonomy of Behaviour Change Techniques for smoking cessation to examine which behaviour change functions are most effective for smoking cessation in people with current depression, 3) Examine the difference in change in depression scores between intervention and control arms.
Methods and Analysis
We will include randomised controlled trials of smokers with current depression as identified by the previous Cochrane review and the in-progress update of the Cochrane review. We will use meta*regression to examine 1) if variations in delivery of mood management impact on smoking cessation intervention effectiveness, 2) determine which behaviour change functions are most effective for smoking cessation and 3) use meta-analysis of the difference in change in depression scores between treatment arms from baseline to follow-up to determine if offering smoking cessation treatment causes psychological harm.
Ethics and Dissemination
Ethical approval is not required for this study. We will disseminate the findings of this work at conferences, and to relevant patient panels.
Registration details
PROSPERO ID: CRD42017070741
| Original language | English |
|---|---|
| Article number | e018617 |
| Number of pages | 6 |
| Journal | BMJ Open |
| Volume | 7 |
| Issue number | 11 |
| Early online date | 16 Nov 2017 |
| DOIs | |
| Publication status | Published - Nov 2017 |
Research Groups and Themes
- Jean Golding
- Bristol Population Health Science Institute
- Brain and Behaviour
- Tobacco and Alcohol
Keywords
- Tobacco
- Smoking cessation
- Depression
- Systematic review
- Protocol
- Intervention
Access to Document
- Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via BMJ Publishing at http://bmjopen.bmj.com/content/7/11/e018617 . Please refer to any applicable terms of use of the publisher.
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Full-text PDF (accepted author manuscript)
Accepted author manuscript, 135 KB
Licence: Unspecified
Embargoed Document
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- 1 Finished
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MRC UoB UNITE Unit - Programme 6
Munafo, M. R. (Principal Investigator) & Munafo, M. R. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research