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Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer: A prospective study in patients with non-small cell lung cancer

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Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer : A prospective study in patients with non-small cell lung cancer. / Avery, Kerry N. L.; Blazeby, Jane M.; Chalmers, Katy A.; Batchelor, Timothy J. P.; Casali, Gianluca; Internullo, Eveline; Krishnadas, Rakesh; Evans, Clare; West, Doug.

In: Annals of Surgical Oncology, 01.12.2019.

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Avery, Kerry N. L. ; Blazeby, Jane M. ; Chalmers, Katy A. ; Batchelor, Timothy J. P. ; Casali, Gianluca ; Internullo, Eveline ; Krishnadas, Rakesh ; Evans, Clare ; West, Doug. / Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer : A prospective study in patients with non-small cell lung cancer. In: Annals of Surgical Oncology. 2019.

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@article{7670503d16224a4ca8288b6a8390aa66,
title = "Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer: A prospective study in patients with non-small cell lung cancer",
abstract = "BackgroundVideo-assisted thoracoscopic surgery (VATS) approaches are increasingly used in lung cancer surgery but little is known about their impact on patients’ health-related quality of life (HRQL). This prospective study measured recovery and HRQL in the year after VATS for non-small cell lung cancer (NSCLC) and explored the feasibility of HRQL data collection in patients undergoing VATS or open lung resection.MethodsConsecutive patients referred for surgical assessment (VATS or open surgery) for proven/suspected NSCLC completed HRQL and fatigue assessments before and 1, 3, 6 and 12 months post-surgery. Mean HRQL scores were calculated for patients who underwent VATS (segmental, wedge or lobectomy resection). Paired t tests compared mean HRQL between baseline and expected worst (1 month), early (3m) and longer-term (12m) recovery time-points.Results92 patients received VATS and 18 open surgery. Questionnaire response rates were high (pre-surgery 96-100{\%}; follow-up 67-85{\%}). Pre-surgery, VATS patients reported mostly high (good) functional health scores (EORTC function scores >80) and low (mild) symptom scores (EORTC symptom scores <20). One-month post-surgery, patients reported clinically and statistically significant deteriorations in overall health and physical, role and social function (range 19-36 points), and increased fatigue, pain, dyspnoea, appetite loss and constipation (EORTC 12-26; MFI-20 3-5). HRQL had not fully recovered 12 months post-surgery, with reduced physical, role and social function (range 10-14) and persistent fatigue and dyspnoea (EORTC 12-22; MFI-20 2.7-3.2).ConclusionLung resection has a considerable detrimental impact on patients’ HRQL that is not fully resolved 12 months post-surgery, despite a VATS approach.",
author = "Avery, {Kerry N. L.} and Blazeby, {Jane M.} and Chalmers, {Katy A.} and Batchelor, {Timothy J. P.} and Gianluca Casali and Eveline Internullo and Rakesh Krishnadas and Clare Evans and Doug West",
year = "2019",
month = "12",
day = "1",
doi = "10.1245/s10434-019-08090-4",
language = "English",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer Verlag",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Impact on health-related quality of life of video-assisted thoracoscopic surgery for lung cancer

T2 - A prospective study in patients with non-small cell lung cancer

AU - Avery, Kerry N. L.

AU - Blazeby, Jane M.

AU - Chalmers, Katy A.

AU - Batchelor, Timothy J. P.

AU - Casali, Gianluca

AU - Internullo, Eveline

AU - Krishnadas, Rakesh

AU - Evans, Clare

AU - West, Doug

PY - 2019/12/1

Y1 - 2019/12/1

N2 - BackgroundVideo-assisted thoracoscopic surgery (VATS) approaches are increasingly used in lung cancer surgery but little is known about their impact on patients’ health-related quality of life (HRQL). This prospective study measured recovery and HRQL in the year after VATS for non-small cell lung cancer (NSCLC) and explored the feasibility of HRQL data collection in patients undergoing VATS or open lung resection.MethodsConsecutive patients referred for surgical assessment (VATS or open surgery) for proven/suspected NSCLC completed HRQL and fatigue assessments before and 1, 3, 6 and 12 months post-surgery. Mean HRQL scores were calculated for patients who underwent VATS (segmental, wedge or lobectomy resection). Paired t tests compared mean HRQL between baseline and expected worst (1 month), early (3m) and longer-term (12m) recovery time-points.Results92 patients received VATS and 18 open surgery. Questionnaire response rates were high (pre-surgery 96-100%; follow-up 67-85%). Pre-surgery, VATS patients reported mostly high (good) functional health scores (EORTC function scores >80) and low (mild) symptom scores (EORTC symptom scores <20). One-month post-surgery, patients reported clinically and statistically significant deteriorations in overall health and physical, role and social function (range 19-36 points), and increased fatigue, pain, dyspnoea, appetite loss and constipation (EORTC 12-26; MFI-20 3-5). HRQL had not fully recovered 12 months post-surgery, with reduced physical, role and social function (range 10-14) and persistent fatigue and dyspnoea (EORTC 12-22; MFI-20 2.7-3.2).ConclusionLung resection has a considerable detrimental impact on patients’ HRQL that is not fully resolved 12 months post-surgery, despite a VATS approach.

AB - BackgroundVideo-assisted thoracoscopic surgery (VATS) approaches are increasingly used in lung cancer surgery but little is known about their impact on patients’ health-related quality of life (HRQL). This prospective study measured recovery and HRQL in the year after VATS for non-small cell lung cancer (NSCLC) and explored the feasibility of HRQL data collection in patients undergoing VATS or open lung resection.MethodsConsecutive patients referred for surgical assessment (VATS or open surgery) for proven/suspected NSCLC completed HRQL and fatigue assessments before and 1, 3, 6 and 12 months post-surgery. Mean HRQL scores were calculated for patients who underwent VATS (segmental, wedge or lobectomy resection). Paired t tests compared mean HRQL between baseline and expected worst (1 month), early (3m) and longer-term (12m) recovery time-points.Results92 patients received VATS and 18 open surgery. Questionnaire response rates were high (pre-surgery 96-100%; follow-up 67-85%). Pre-surgery, VATS patients reported mostly high (good) functional health scores (EORTC function scores >80) and low (mild) symptom scores (EORTC symptom scores <20). One-month post-surgery, patients reported clinically and statistically significant deteriorations in overall health and physical, role and social function (range 19-36 points), and increased fatigue, pain, dyspnoea, appetite loss and constipation (EORTC 12-26; MFI-20 3-5). HRQL had not fully recovered 12 months post-surgery, with reduced physical, role and social function (range 10-14) and persistent fatigue and dyspnoea (EORTC 12-22; MFI-20 2.7-3.2).ConclusionLung resection has a considerable detrimental impact on patients’ HRQL that is not fully resolved 12 months post-surgery, despite a VATS approach.

U2 - 10.1245/s10434-019-08090-4

DO - 10.1245/s10434-019-08090-4

M3 - Article

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

ER -