Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults

Sarah J Glennie, Enoch Sepako, David Mzinza, Visopo Harawa, David J C Miles, Kondwani C Jambo, Stephen B Gordon, Neil A Williams, Robert S Heyderman

Research output: Contribution to journalArticle (Academic Journal)peer-review

24 Citations (Scopus)

Abstract

Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased risk of IPD. This study evaluated the extent of pneumococcal-specific T cell memory dysfunction in asymptomatic HIV infection early on in the evolution of the disease.
Original languageEnglish
Pages (from-to)e25610
JournalPLoS ONE
Volume6
Issue number9
DOIs
Publication statusPublished - 2011

Keywords

  • Young Adult
  • T-Lymphocytes, Regulatory
  • Interferon-gamma
  • Humans
  • Asymptomatic Infections
  • Cell Proliferation
  • CD4-Positive T-Lymphocytes
  • CD40 Ligand
  • Streptococcus pneumoniae
  • Cell Aging
  • HIV Infections
  • Adult
  • Case-Control Studies
  • Middle Aged
  • Up-Regulation
  • Malawi
  • Adolescent
  • Species Specificity
  • Interleukin-17
  • Male
  • Female

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