Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults

Sarah J Glennie; Enoch Sepako; David Mzinza; Visopo Harawa; David J C Miles; Kondwani C Jambo; Stephen B Gordon; Neil A Williams; Robert S Heyderman

doi:10.1371/journal.pone.0025610

Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults

Sarah J Glennie, Enoch Sepako, David Mzinza, Visopo Harawa, David J C Miles, Kondwani C Jambo, Stephen B Gordon, Neil A Williams, Robert S Heyderman

Research output: Contribution to journal › Article (Academic Journal) › peer-review

27 Citations (Scopus)

Abstract

Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased risk of IPD. This study evaluated the extent of pneumococcal-specific T cell memory dysfunction in asymptomatic HIV infection early on in the evolution of the disease.

Original language	English
Pages (from-to)	e25610
Journal	PLOS ONE
Volume	6
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0025610
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Young Adult
T-Lymphocytes, Regulatory
Interferon-gamma
Humans
Asymptomatic Infections
Cell Proliferation
CD4-Positive T-Lymphocytes
CD40 Ligand
Streptococcus pneumoniae
Cell Aging
HIV Infections
Adult
Case-Control Studies
Middle Aged
Up-Regulation
Malawi
Adolescent
Species Specificity
Interleukin-17
Male
Female

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title = "Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults",

abstract = "Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased risk of IPD. This study evaluated the extent of pneumococcal-specific T cell memory dysfunction in asymptomatic HIV infection early on in the evolution of the disease.",

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author = "Glennie, \{Sarah J\} and Enoch Sepako and David Mzinza and Visopo Harawa and Miles, \{David J C\} and Jambo, \{Kondwani C\} and Gordon, \{Stephen B\} and Williams, \{Neil A\} and Heyderman, \{Robert S\}",

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T1 - Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults

AU - Glennie, Sarah J

AU - Sepako, Enoch

AU - Mzinza, David

AU - Harawa, Visopo

AU - Miles, David J C

AU - Jambo, Kondwani C

AU - Gordon, Stephen B

AU - Williams, Neil A

AU - Heyderman, Robert S

PY - 2011

Y1 - 2011

N2 - Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased risk of IPD. This study evaluated the extent of pneumococcal-specific T cell memory dysfunction in asymptomatic HIV infection early on in the evolution of the disease.

AB - Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at increased risk of IPD. This study evaluated the extent of pneumococcal-specific T cell memory dysfunction in asymptomatic HIV infection early on in the evolution of the disease.

KW - Young Adult

KW - T-Lymphocytes, Regulatory

KW - Interferon-gamma

KW - Humans

KW - Asymptomatic Infections

KW - Cell Proliferation

KW - CD4-Positive T-Lymphocytes

KW - CD40 Ligand

KW - Streptococcus pneumoniae

KW - Cell Aging

KW - HIV Infections

KW - Adult

KW - Case-Control Studies

KW - Middle Aged

KW - Up-Regulation

KW - Malawi

KW - Adolescent

KW - Species Specificity

KW - Interleukin-17

KW - Male

KW - Female

U2 - 10.1371/journal.pone.0025610

DO - 10.1371/journal.pone.0025610

M3 - Article (Academic Journal)

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SN - 1932-6203

VL - 6

SP - e25610

JO - PLOS ONE

JF - PLOS ONE

IS - 9

ER -

Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults

Abstract

UN SDGs

Keywords

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