Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey

Akira Yoshida; Minchul Kim; Masataka Kuwana; Naveen Ravichandran; Ashima Makol; Parikshit Sen; James B Lilleker; Vishwesh Agarwal; Sinan Kardes; Jessica Day; Marcin Milchert; Mrudula Joshi; Tamer Gheita; Babur Salim; Tsvetelina Velikova; Abraham Edgar Gracia-Ramos; Ioannis Parodis; Albert Selva O'Callaghan; Elena Nikiphorou; Tulika Chatterjee; Ai Lyn Tan; Arvind Nune; Lorenzo Cavagna; Miguel A Saavedra; Samuel Katsuyuki Shinjo; Nelly Ziade; Johannes Knitza; Oliver Distler; Hector Chinoy; Vikas Agarwal; John D Pauling; COVAD Study Group; et al

doi:10.1093/rheumatology/keac441

Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey

Akira Yoshida, Minchul Kim, Masataka Kuwana, Naveen Ravichandran, Ashima Makol, Parikshit Sen, James B Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Elena Nikiphorou, Tulika ChatterjeeAi Lyn Tan, Arvind Nune, Lorenzo Cavagna, Miguel A Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Oliver Distler, Hector Chinoy, Vikas Agarwal, John D Pauling, COVAD Study Group , et al

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Abstract

Objectives:

The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs.

Methods:

Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease.

Results:

A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P < 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis.

Conclusion:

Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.

Original language	English
Pages (from-to)	1204-1215
Number of pages	12
Journal	Rheumatology (Oxford, England)
Volume	62
Issue number	3
Early online date	3 Aug 2022
DOIs	https://doi.org/10.1093/rheumatology/keac441
Publication status	Published - 1 Mar 2023

Bibliographical note

Publisher Copyright:
© The Author(s) 2022.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Humans
Female
COVID-19 Vaccines
COVID-19
Myositis/diagnosis
Rheumatic Diseases
Patient Reported Outcome Measures

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Yoshida, A., Kim, M., Kuwana, M., Ravichandran, N., Makol, A., Sen, P., Lilleker, J. B., Agarwal, V., Kardes, S., Day, J., Milchert, M., Joshi, M., Gheita, T., Salim, B., Velikova, T., Edgar Gracia-Ramos, A., Parodis, I., Selva O'Callaghan, A., Nikiphorou, E., ... al , E. (2023). Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey. Rheumatology (Oxford, England), 62(3), 1204-1215. https://doi.org/10.1093/rheumatology/keac441

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title = "Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey",

abstract = "Objectives:The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs. Methods:Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease. Results:A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95\% CI 35.5, 37.1) vs 41.3 (95\% CI 40.2, 42.5) vs 46.2 (95\% CI 45.8, 46.6), P < 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis. Conclusion:Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.",

keywords = "Humans, Female, COVID-19 Vaccines, COVID-19, Myositis/diagnosis, Rheumatic Diseases, Patient Reported Outcome Measures",

author = "Akira Yoshida and Minchul Kim and Masataka Kuwana and Naveen Ravichandran and Ashima Makol and Parikshit Sen and Lilleker, \{James B\} and Vishwesh Agarwal and Sinan Kardes and Jessica Day and Marcin Milchert and Mrudula Joshi and Tamer Gheita and Babur Salim and Tsvetelina Velikova and \{Edgar Gracia-Ramos\}, Abraham and Ioannis Parodis and \{Selva O'Callaghan\}, Albert and Elena Nikiphorou and Tulika Chatterjee and Tan, \{Ai Lyn\} and Arvind Nune and Lorenzo Cavagna and Saavedra, \{Miguel A\} and Shinjo, \{Samuel Katsuyuki\} and Nelly Ziade and Johannes Knitza and Oliver Distler and Hector Chinoy and Vikas Agarwal and Pauling, \{John D\} and \{COVAD Study Group\} and et al",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. ",

year = "2023",

month = mar,

day = "1",

doi = "10.1093/rheumatology/keac441",

language = "English",

volume = "62",

pages = "1204--1215",

journal = "Rheumatology (Oxford, England)",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "3",

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Yoshida, A, Kim, M, Kuwana, M, Ravichandran, N, Makol, A, Sen, P, Lilleker, JB, Agarwal, V, Kardes, S, Day, J, Milchert, M, Joshi, M, Gheita, T, Salim, B, Velikova, T, Edgar Gracia-Ramos, A, Parodis, I, Selva O'Callaghan, A, Nikiphorou, E, Chatterjee, T, Tan, AL, Nune, A, Cavagna, L, Saavedra, MA, Shinjo, SK, Ziade, N, Knitza, J, Distler, O, Chinoy, H, Agarwal, V, Pauling, JD, COVAD Study Group & al , E 2023, 'Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey', Rheumatology (Oxford, England), vol. 62, no. 3, pp. 1204-1215. https://doi.org/10.1093/rheumatology/keac441

TY - JOUR

T1 - Impaired physical function in patients with idiopathic inflammatory myopathies

T2 - results from the multicentre COVAD patient-reported e-survey

AU - Yoshida, Akira

AU - Kim, Minchul

AU - Kuwana, Masataka

AU - Ravichandran, Naveen

AU - Makol, Ashima

AU - Sen, Parikshit

AU - Lilleker, James B

AU - Agarwal, Vishwesh

AU - Kardes, Sinan

AU - Day, Jessica

AU - Milchert, Marcin

AU - Joshi, Mrudula

AU - Gheita, Tamer

AU - Salim, Babur

AU - Velikova, Tsvetelina

AU - Edgar Gracia-Ramos, Abraham

AU - Parodis, Ioannis

AU - Selva O'Callaghan, Albert

AU - Nikiphorou, Elena

AU - Chatterjee, Tulika

AU - Tan, Ai Lyn

AU - Nune, Arvind

AU - Cavagna, Lorenzo

AU - Saavedra, Miguel A

AU - Shinjo, Samuel Katsuyuki

AU - Ziade, Nelly

AU - Knitza, Johannes

AU - Distler, Oliver

AU - Chinoy, Hector

AU - Agarwal, Vikas

AU - Pauling, John D

AU - COVAD Study Group

AU - al , et

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Objectives:The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs. Methods:Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease. Results:A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P < 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis. Conclusion:Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.

AB - Objectives:The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs. Methods:Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease. Results:A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P < 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis. Conclusion:Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.

KW - Humans

KW - Female

KW - COVID-19 Vaccines

KW - COVID-19

KW - Myositis/diagnosis

KW - Rheumatic Diseases

KW - Patient Reported Outcome Measures

U2 - 10.1093/rheumatology/keac441

DO - 10.1093/rheumatology/keac441

M3 - Article (Academic Journal)

C2 - 35920795

SN - 1462-0324

VL - 62

SP - 1204

EP - 1215

JO - Rheumatology (Oxford, England)

JF - Rheumatology (Oxford, England)

IS - 3

ER -

Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey

Abstract

Bibliographical note

UN SDGs

Keywords

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