Impairment of pneumococcal antigen specific isotype-switched Igg memory B-cell immunity in HIV infected Malawian adults

Oluwadamilola H Iwajomo, Adam Finn, Abiodun D Ogunniyi, Neil A Williams, Robert S Heyderman

Research output: Contribution to journalArticle (Academic Journal)peer-review

9 Citations (Scopus)

Abstract

Pneumococcal disease is associated with a particularly high morbidity and mortality amongst adults in HIV endemic countries. Our previous findings implicating a B-cell defect in HIV-infected children from the same population led us to comprehensively characterize B-cell subsets in minimally symptomatic HIV-infected Malawian adults and investigate the isotype-switched IgG memory B-cell immune response to the pneumococcus. We show that similar to vertically acquired HIV-infected Malawian children, horizontally acquired HIV infection in these adults is associated with IgM memory B-cell (CD19(+) CD27(+) IgM(+) IgD(+)) depletion, B-cell activation and impairment of specific IgG B-cell memory to a range of pneumococcal proteins. Our data suggest that HIV infection affects both T-cell independent and T-cell dependent B-cell maturation, potentially leading to impairment of humoral responses to extracellular pathogens such as the pneumococcus, and thus leaving this population susceptible to invasive disease.

Original languageEnglish
Pages (from-to)e78592
JournalPLoS ONE
Volume8
Issue number11
DOIs
Publication statusPublished - 2013

Keywords

  • Adult
  • Antigens, Bacterial
  • B-Lymphocyte Subsets
  • Case-Control Studies
  • Female
  • HIV
  • HIV Infections
  • Humans
  • Immunoglobulin Class Switching
  • Immunoglobulin G
  • Immunoglobulin M
  • Immunologic Memory
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Malawi
  • Male
  • Pneumonia, Pneumococcal
  • Streptococcus pneumoniae

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