Importance and contribution of community, social, and healthcare risk factors for Hepatitis C infection in Pakistan

Adam Trickey*, Margaret May, Charlotte Davies, Huma Qureshi, Saeed Hamid, Hassan Mahmood, Quaid Saeed, Matthew Hickman, Nancy Glass, Francisco Averhoff, Peter Vickerman

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)
187 Downloads (Pure)

Abstract

Pakistan has a high prevalence of hepatitis C virus (HCV) infection, estimated at 4.9% (2,290/46,843) in the 2007 national HCV sero-prevalence survey. We used data from this survey to assess the importance of risk factor associations with HCV prevalence in Pakistan. Exposures were grouped as community (going to the barbers, sharing smoking equipment, having an ear/nose piercing, tattoo or acupuncture), healthcare (ever having haemodialysis, blood transfusion, or ≥5 injections in the last year), demographic (marital status and age), and socio-economic (illiterate or labourer). We used mutually adjusted multivariable regression analysis, stratified by sex, to determine associations with HCV infection, their population attributable fraction, and how risk of infection accumulates with multiple exposures. Strength of associations were assessed using adjusted odds ratios (aOR). Community [aOR females 1.5(95% CI 1.2,1.8); males 1.2(1.1,1.4)] and healthcare [females 1.4(1.2,1.6); males 1.2(1.1,1.4)] exposures, low socio-economic status [females 1.6(1.3,1.80); males 1.3(1.2,1.5)], and marriage [females 1.5(1.2,1.9); males 1.4(1.1,1.8)] were associated with increased HCV infection. Among married women, the number of children was associated with an increase in HCV infection; linear trend aOR per child 1.06 (1.01,1.11). Fewer infections could be attributed to healthcare exposures (females 13%; males 6%) than to community exposures (females 25%; males 9%). Prevalence increased from 3% to 10% when cumulative exposures increased from 1 to ≥4 [aOR per additional exposure for females 1.5(1.4,1.6); males 1.2(1.2,1.3)].
A combination of community, healthcare and other factors appear to drive the Pakistan HCV epidemic, highlighting the need for a comprehensive array of prevention strategies.
Original languageEnglish
Pages (from-to)1920-1928
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume97
Issue number6
DOIs
Publication statusPublished - 1 Dec 2017

Keywords

  • Hepatitis C
  • Pakistan
  • Risk factors
  • Sero-prevalence survey
  • Population attributable fraction

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