A general method for the preparation of virtually any potassium trifluoroborate salt from the corresponding pinacolboronic ester is reported. Thus, conditions for an azeotropic removal of pinacol from the reaction mixture were found to afford the desired potassium trifluoroborates Of Sufficient purity (>95%) in nearly quantitative yields irrespective of the nature of the product. The utility of this method is illustrated by the preparation of a broad range of enantioenriched secondary and tertiary potassium trifluoroborates. (C) 2009 Elsevier Ltd. All rights reserved.
- CROSS-COUPLING REACTIONS
- EXPANDING ORGANOBORON CHEMISTRY
- RHODIUM-CATALYZED ADDITION