Improving cellularisation of tissue endgineered vascular grafts using functionalised peptide hydrogels

Nick W Schumacker; Gianni Angelini; Sarah George; Raimondo Ascione

Improving cellularisation of tissue endgineered vascular grafts using functionalised peptide hydrogels

Nick W Schumacker, Gianni Angelini, Sarah George, Raimondo Ascione

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Tissue engineered vascular grafts have the potential to replace saphenous vein for multiple small diameter (<6mm) coronary artery bypass grafts, which offer relatively poor long term patency rates, often leading to repeat surgeries. Despite their potential, first generation vascular grafts have failed to provide superior patency rates when compared to saphenous vein grafts. One of main reasons for early graft failure is thrombus formation, which is attributed to an inadequate or absent luminal endothelial monolayer.

Original language	English
Pages (from-to)	e10
Journal	Atherosclerosis
Volume	244
Publication status	Published - 1 Jan 2016

Structured keywords

Centre for Surgical Research

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title = "Improving cellularisation of tissue endgineered vascular grafts using functionalised peptide hydrogels",

abstract = "Tissue engineered vascular grafts have the potential to replace saphenous vein for multiple small diameter (<6mm) coronary artery bypass grafts, which offer relatively poor long term patency rates, often leading to repeat surgeries. Despite their potential, first generation vascular grafts have failed to provide superior patency rates when compared to saphenous vein grafts. One of main reasons for early graft failure is thrombus formation, which is attributed to an inadequate or absent luminal endothelial monolayer.",

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T1 - Improving cellularisation of tissue endgineered vascular grafts using functionalised peptide hydrogels

AU - Schumacker, Nick W

AU - Angelini, Gianni

AU - George, Sarah

AU - Ascione, Raimondo

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Tissue engineered vascular grafts have the potential to replace saphenous vein for multiple small diameter (<6mm) coronary artery bypass grafts, which offer relatively poor long term patency rates, often leading to repeat surgeries. Despite their potential, first generation vascular grafts have failed to provide superior patency rates when compared to saphenous vein grafts. One of main reasons for early graft failure is thrombus formation, which is attributed to an inadequate or absent luminal endothelial monolayer.

AB - Tissue engineered vascular grafts have the potential to replace saphenous vein for multiple small diameter (<6mm) coronary artery bypass grafts, which offer relatively poor long term patency rates, often leading to repeat surgeries. Despite their potential, first generation vascular grafts have failed to provide superior patency rates when compared to saphenous vein grafts. One of main reasons for early graft failure is thrombus formation, which is attributed to an inadequate or absent luminal endothelial monolayer.

M3 - Article (Academic Journal)

VL - 244

SP - e10

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -