In the Balance: How do Thrombospondins Contribute to the Cellular Pathophysiology of Cardiovascular Disease?

Tessa Forbes, Audrys G Pauza, Josephine C Adams

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Thrombospondins (TSPs) are multi-domain, secreted proteins that associate with cell-surfaces and extracellular matrix. In mammals, there is a large body of data on functional roles of various TSP family members in cardiovascular disease (CVD), including stroke, cardiac remodelling and fibrosis, atherosclerosis and aortic aneurysms. Coding single nucleotide polymorphisms (SNPs) of TSP1 or TSP4 are also associated with increased risk of several forms of CVD. Whereas interactions and functional effects of TSPs on a variety of cell types have been studied extensively, the molecular and cellular basis for the differential effects of the SNPs remains under investigation. Here, we provide an integrative review on TSPs, their roles in CVD and cardiovascular cell physiology, and known properties and mechanisms of TSP SNPs relevant to CVD. In considering recent expansions to knowledge of the fundamental cellular roles and mechanisms of TSPs, as well as the effects of wild-type and variant TSPs on cells of the cardiovascular system, we aim to highlight knowledge gaps and areas for future research or of translational potential.

Original languageEnglish
Pages (from-to)C826-C845
JournalAmerican journal of physiology. Cell physiology
Volume321
Issue number5
Early online date8 Sep 2021
DOIs
Publication statusPublished - 1 Nov 2021

Bibliographical note

Funding Information:
T. Forbes and A. G. Pauza are funded by the British Heart Foundation (FS/17/60/33474).

Publisher Copyright:
Copyright © 2021 the American Physiological Society.

Fingerprint

Dive into the research topics of 'In the Balance: How do Thrombospondins Contribute to the Cellular Pathophysiology of Cardiovascular Disease?'. Together they form a unique fingerprint.

Cite this