In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids

Zi Gu, Anita C Thomas, Zhi Ping Xu, Julie Campbell, Gao Qing Lu

Research output: Contribution to journalArticle (Academic Journal)peer-review

221 Citations (Scopus)

Abstract

Magnesium-aluminum-chloride-layered double hydroxides (MgAl-Cl-LDHs) intercalated with low molecular weight heparin (LMWH) were prepared for the first time by the coprecipitation method and then characterized by XRD, elemental analysis, FTIR, SEM, and TEM. MgAl-LDH was studied as the drug carrier for LMWH, a widely used anticoagulant, in order to overcome some of its pharmaceutical limitations, such as its short half-life. In vitro release tests of LMWH-LDH in pH 7.4 PBS at 37 ¦C show a biphasic and sustained profile of LMWH anion release with ~20% in the first 12 h and another ~20% in the following 108 h. After release, the residue was characterized and dissolutiondiffusion kinetic models fitted. The mechanism of MgAl-LMWH-LDH release is probably due to surface diffusion and bulk diffusion via anionic exchange of LMWH anions on or in the LDH with anions in the PBS solution
Original languageEnglish
Pages (from-to)3715-3722
Number of pages8
JournalChemistry of Materials
Volume20
Issue number11
Publication statusPublished - 2008

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