In vivo gene transfer to dissect neuronal mechanisms regulating cardiorespiratory function

Julian F R Paton, Hidefumi Waki, Sergey Kasparov

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)

Abstract

This lecture reviews recent information from our laboratory regarding brainstem mechanisms regulating the arterial baroreceptor reflex. Our long-term goal is to understand some of the mechanisms involved in the etiology of essential hypertension. Our hypothesis is that this problem may arise, in part, because of changes within brainstem circuits controlling arterial pressure, and in particular to occlusion of baroreceptive information at the level of the primary afferent relay within the brainstem. Although it is established that baroreceptors provide a mechanism for short-term regulation of arterial pressure, there is convincing evidence that they also play a role in its long-term control (see Thrasher 2002, for an example). It follows that dysfunction of this reflex circuit could contribute to high blood pressure levels. Here, we discuss the central actions of angiotensin II on the baroreceptor reflex circuitry within the nucleus of the solitary tract (NTS) for arterial pressure control. Our findings have led us to hypothesize a novel form of intercellular communication within the NTS, one of vascular-neuronal signaling.

Original languageEnglish
Pages (from-to)311-6
Number of pages6
JournalCanadian Journal of Physiology and Pharmacology
Volume81
Issue number4
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Angiotensin II
  • Baroreflex
  • Blood Pressure
  • Gene Transfer Techniques
  • Humans
  • Muscle, Smooth, Vascular
  • Neural Pathways
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III
  • Signal Transduction
  • Solitary Nucleus

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