nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa

Y Morita, L Cao, VC Gould, MB Avison, K Poole

Research output: Contribution to journalArticle (Academic Journal)peer-review

47 Citations (Scopus)

Abstract

The Pseudomonas aeruginosa nalD gene encodes a TetR family repressor with homology to the SmeT and TtgR repressors of the smeDEF and ttgABC multidrug efflux systems of Stenotrophomonas maltophilia and Pseudomonas putida, respectively. A sequence upstream of mexAB-oprM and overlapping a second promoter for this efflux system was very similar to the SmeT and TtgR operator sequences, and NalD binding to this region was, in fact, demonstrated. Moreover, increased expression from this promoter was seen in a nalD mutant, consistent with NalD directly controlling mexAB-oprM expression from a second promoter.
Translated title of the contributionnalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa
Original languageEnglish
Pages (from-to)8649 - 8654
Number of pages6
JournalJournal of Bacteriology
Volume188 (24)
DOIs
Publication statusPublished - Dec 2006

Bibliographical note

Publisher: American Society of Medicine

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