TY - JOUR
T1 - Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure
AU - Fonfara, S
AU - Tew, S R
AU - Cripps, P
AU - Dukes-McEwan, J
AU - Clegg, P D
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P
AB - Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P
U2 - 10.1016/j.rvsc.2011.10.020
DO - 10.1016/j.rvsc.2011.10.020
M3 - Article (Academic Journal)
C2 - 22100243
SN - 0034-5288
VL - 93
SP - 879
EP - 885
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 2
ER -