Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure

S Fonfara; S R Tew; P Cripps; J Dukes-McEwan; P D Clegg

doi:10.1016/j.rvsc.2011.10.020

Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure

S Fonfara, S R Tew, P Cripps, J Dukes-McEwan, P D Clegg

Bristol Veterinary School

Research output: Contribution to journal › Article (Academic Journal) › peer-review

11 Citations (Scopus)

Abstract

Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P

Original language	English
Pages (from-to)	879-85
Number of pages	7
Journal	Research in Veterinary Science
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/j.rvsc.2011.10.020
Publication status	Published - 2012

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title = "Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure",

abstract = "Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P",

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year = "2012",

doi = "10.1016/j.rvsc.2011.10.020",

language = "English",

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pages = "879--85",

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T1 - Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure

AU - Fonfara, S

AU - Tew, S R

AU - Cripps, P

AU - Dukes-McEwan, J

AU - Clegg, P D

PY - 2012

Y1 - 2012

N2 - Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P

AB - Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P

U2 - 10.1016/j.rvsc.2011.10.020

DO - 10.1016/j.rvsc.2011.10.020

M3 - Article (Academic Journal)

C2 - 22100243

SN - 0034-5288

VL - 93

SP - 879

EP - 885

JO - Research in Veterinary Science

JF - Research in Veterinary Science

IS - 2

ER -

Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure

Abstract

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