Abstract
The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.
| Original language | English |
|---|---|
| Pages (from-to) | 281-4 |
| Number of pages | 4 |
| Journal | European Archives of Psychiatry and Clinical Neuroscience |
| Volume | 266 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 2016 |
Keywords
- Animals
- Brain-Derived Neurotrophic Factor/analysis
- Enzyme-Linked Immunosorbent Assay/methods
- Hippocampus/chemistry
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Prefrontal Cortex/chemistry
- Serotonin/deficiency
- Serotonin Plasma Membrane Transport Proteins/deficiency
- Tryptophan Hydroxylase/deficiency
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