Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women

Debbie A Lawlor; Abigail Fraser; Shah Ebrahim; George Davey Smith

doi:10.1371/journal.pmed.0040263

Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women

Debbie A Lawlor, Abigail Fraser, Shah Ebrahim, George Davey Smith

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular disease in women without diabetes is unclear. Our aim was to determine the independent associations of fasting insulin, glucose, and glycated haemoglobin with coronary heart disease and stroke in older women.

Original language	English
Pages (from-to)	e263
Journal	PLoS Medicine
Volume	4
Issue number	8
DOIs	https://doi.org/10.1371/journal.pmed.0040263
Publication status	Published - Aug 2007

Keywords

Age Factors
Aged
Blood Glucose
Cohort Studies
Coronary Disease
Diabetes Mellitus
Enzyme-Linked Immunosorbent Assay
Exercise
Fasting
Female
Hemoglobin A, Glycosylated
Humans
Insulin
Insulin Resistance
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
Smoking
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women",

abstract = "Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular disease in women without diabetes is unclear. Our aim was to determine the independent associations of fasting insulin, glucose, and glycated haemoglobin with coronary heart disease and stroke in older women.",

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T1 - Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women

AU - Lawlor, Debbie A

AU - Fraser, Abigail

AU - Ebrahim, Shah

AU - Smith, George Davey

PY - 2007/8

Y1 - 2007/8

N2 - Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular disease in women without diabetes is unclear. Our aim was to determine the independent associations of fasting insulin, glucose, and glycated haemoglobin with coronary heart disease and stroke in older women.

AB - Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular disease in women without diabetes is unclear. Our aim was to determine the independent associations of fasting insulin, glucose, and glycated haemoglobin with coronary heart disease and stroke in older women.

KW - Age Factors

KW - Aged

KW - Blood Glucose

KW - Cohort Studies

KW - Coronary Disease

KW - Diabetes Mellitus

KW - Enzyme-Linked Immunosorbent Assay

KW - Exercise

KW - Fasting

KW - Female

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Middle Aged

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Smoking

KW - Stroke

U2 - 10.1371/journal.pmed.0040263

DO - 10.1371/journal.pmed.0040263

M3 - Article (Academic Journal)

C2 - 17760500

SN - 1549-1277

VL - 4

SP - e263

JO - PLoS Medicine

JF - PLoS Medicine

IS - 8

ER -

Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women

Abstract

Keywords

UN SDGs

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