Abstract
Peptide helices containing L-amino acids are typically right-handed. Exceptions are peptide helices containing the achiral amino acids 2-aminoisobutyric acid and glycine with a single chiral amino acid at the Nterminus. These helices are left-handed when the N-terminal residue is a common tertiary proteinogenic amino acid, such as L-valine (see picture, left), but right-handed when the N-terminal residue is the quaternary amino acid L-α-methylvaline (right).
Original language | English |
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Pages (from-to) | 1395-1399 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 6 |
Early online date | 3 Jan 2012 |
DOIs | |
Publication status | Published - 6 Feb 2012 |
Keywords
- circular dichroism
- conformation analysis
- foldamers
- helical structures
- peptides