Inferring transcriptional modules from ChIP-chip, motif and microarray data

K Lemmens, T D'Hollander, TEP De Bie, P Monsieurs, K Engelen, B Smets, J Winderickx, B De Moor, K Marchal

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)

Abstract

'ReMoDiscovery' is an intuitive algorithm to correlate regulatory programs with regulators and corresponding motifs to a set of co-expressed genes. It exploits in a concurrent way three independent data sources: ChIP-chip data, motif information and gene expression profiles. When compared to published module discovery algorithms, ReMoDiscovery is fast and easily tunable. We evaluated our method on yeast data, where it was shown to generate biologically meaningful findings and allowed the prediction of potential novel roles of transcriptional regulators.
Original languageEnglish
Pages (from-to)R37.1 - R37.14
Number of pages14
JournalGenome Biology
Volume7 (5, R37)
DOIs
Publication statusPublished - May 2006

Bibliographical note

Publisher: BioMed Central

Fingerprint Dive into the research topics of 'Inferring transcriptional modules from ChIP-chip, motif and microarray data'. Together they form a unique fingerprint.

  • Cite this

    Lemmens, K., D'Hollander, T., De Bie, TEP., Monsieurs, P., Engelen, K., Smets, B., Winderickx, J., De Moor, B., & Marchal, K. (2006). Inferring transcriptional modules from ChIP-chip, motif and microarray data. Genome Biology, 7 (5, R37), R37.1 - R37.14. https://doi.org/10.1186/gb-2006-7-5-r37