Inflammation and Depression: A Public Health Perspective

Alexander L. Chu; Matt  Hickman; Nicholas Steel; Peter  Jones; George Davey Smith; Golam Khandaker

doi:10.1016/j.bbi.2021.04.015

Inflammation and Depression: A Public Health Perspective

Alexander L. Chu^*
, Matt Hickman
, Nicholas Steel
, Peter Jones
, George Davey Smith
, Golam Khandaker

^*Corresponding author for this work

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

40 Citations (Scopus)

168 Downloads (Pure)

Abstract

The multifaceted role of low-grade systemic inflammation in depression and physical illnesses like cardiovascular disease highlights complex interactions between the body, brain and mind. While current research on inflammation and depression has largely focused on exploring possible disease mechanisms and therapeutic potential, we seek to broaden the current discussion by introducing a public health perspective. In this Viewpoint, we propose that inflammation and its contributing sources could represent important targets for public health strategies aimed at improving both mental and physical health. We discuss potential universal, selective and indicated primary prevention strategies for inflammation-related depression. We consider potential approaches to secondary prevention, including scope for anti-inflammatory treatment and CRP testing for guiding treatment allocation and prognosis. Preventive strategies discussed here could also be relevant for other inflammation-mediated mental health conditions.v

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Brain, Behavior, and Immunity
Volume	95
Early online date	18 Apr 2021
DOIs	https://doi.org/10.1016/j.bbi.2021.04.015
Publication status	Published - 1 Jul 2021

Bibliographical note

Funding Information:
GMK acknowledges funding support from the Wellcome Trust (grant code: 201486/Z/16/Z), the MQ: Transforming Mental Health (grant code: MQDS17/40), the Medical Research Council UK (grant code: MC_PC_17213 and MR/S037675/1) and the BMA Foundation (J Moulton grant 2019). GDS & GMK work in the Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol (MC_UU_00011/1). PBJ acknowledges funding from the MRC and MQ (grant code: MQDS17/40), programmatic funding from NIHR (RP-PG-0616-20003) and support from the Applied Research Collaboration East of England. MH acknowledges support from the NIHR BRC at Bristol and the NIHR HPRU in Behavioural Science and Evaluation.

Funding Information:
This research was funded in whole, or in part, by the Wellcome Trust [Grant number 201486/Z/16/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. This work is licensed under a Creative Commons Attribution 4.0 International License.

Funding Information:
We are grateful to Mr. Peter Templeton, Executive Director of IfM Education and Consultancy Service, a University of Cambridge knowledge transfer company, and Founder of the mental health charity The Foundation for Young People's Mental Health, for his helpful comments.

Publisher Copyright:
© 2021 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mental Health
Depression
Immunopsychiatry
Inflammation
Public Health
Prevention

Access to Document

10.1016/j.bbi.2021.04.015

Full-text PDF (author’s accepted manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.bbi.2021.04.015 . Please refer to any applicable terms of use of the publisher. This research was funded in whole, or in part, by the Wellcome Trust [Grant number 201486/Z/16/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted author manuscript, 264 KBLicence: CC BY

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Persistent link

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

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abstract = "The multifaceted role of low-grade systemic inflammation in depression and physical illnesses like cardiovascular disease highlights complex interactions between the body, brain and mind. While current research on inflammation and depression has largely focused on exploring possible disease mechanisms and therapeutic potential, we seek to broaden the current discussion by introducing a public health perspective. In this Viewpoint, we propose that inflammation and its contributing sources could represent important targets for public health strategies aimed at improving both mental and physical health. We discuss potential universal, selective and indicated primary prevention strategies for inflammation-related depression. We consider potential approaches to secondary prevention, including scope for anti-inflammatory treatment and CRP testing for guiding treatment allocation and prognosis. Preventive strategies discussed here could also be relevant for other inflammation-mediated mental health conditions.v",

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author = "Chu, \{Alexander L.\} and Matt Hickman and Nicholas Steel and Peter Jones and \{Davey Smith\}, George and Golam Khandaker",

note = "Funding Information: GMK acknowledges funding support from the Wellcome Trust (grant code: 201486/Z/16/Z), the MQ: Transforming Mental Health (grant code: MQDS17/40), the Medical Research Council UK (grant code: MC\_PC\_17213 and MR/S037675/1) and the BMA Foundation (J Moulton grant 2019). GDS \& GMK work in the Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol (MC\_UU\_00011/1). PBJ acknowledges funding from the MRC and MQ (grant code: MQDS17/40), programmatic funding from NIHR (RP-PG-0616-20003) and support from the Applied Research Collaboration East of England. MH acknowledges support from the NIHR BRC at Bristol and the NIHR HPRU in Behavioural Science and Evaluation. Funding Information: This research was funded in whole, or in part, by the Wellcome Trust [Grant number 201486/Z/16/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. This work is licensed under a Creative Commons Attribution 4.0 International License. Funding Information: We are grateful to Mr. Peter Templeton, Executive Director of IfM Education and Consultancy Service, a University of Cambridge knowledge transfer company, and Founder of the mental health charity The Foundation for Young People's Mental Health, for his helpful comments. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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AU - Chu, Alexander L.

AU - Hickman, Matt

AU - Steel, Nicholas

AU - Jones, Peter

AU - Davey Smith, George

AU - Khandaker, Golam

N1 - Funding Information: GMK acknowledges funding support from the Wellcome Trust (grant code: 201486/Z/16/Z), the MQ: Transforming Mental Health (grant code: MQDS17/40), the Medical Research Council UK (grant code: MC_PC_17213 and MR/S037675/1) and the BMA Foundation (J Moulton grant 2019). GDS & GMK work in the Medical Research Council Integrative Epidemiology Unit (IEU) at the University of Bristol (MC_UU_00011/1). PBJ acknowledges funding from the MRC and MQ (grant code: MQDS17/40), programmatic funding from NIHR (RP-PG-0616-20003) and support from the Applied Research Collaboration East of England. MH acknowledges support from the NIHR BRC at Bristol and the NIHR HPRU in Behavioural Science and Evaluation. Funding Information: This research was funded in whole, or in part, by the Wellcome Trust [Grant number 201486/Z/16/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. This work is licensed under a Creative Commons Attribution 4.0 International License. Funding Information: We are grateful to Mr. Peter Templeton, Executive Director of IfM Education and Consultancy Service, a University of Cambridge knowledge transfer company, and Founder of the mental health charity The Foundation for Young People's Mental Health, for his helpful comments. Publisher Copyright: © 2021 Elsevier Inc.

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Y1 - 2021/7/1

N2 - The multifaceted role of low-grade systemic inflammation in depression and physical illnesses like cardiovascular disease highlights complex interactions between the body, brain and mind. While current research on inflammation and depression has largely focused on exploring possible disease mechanisms and therapeutic potential, we seek to broaden the current discussion by introducing a public health perspective. In this Viewpoint, we propose that inflammation and its contributing sources could represent important targets for public health strategies aimed at improving both mental and physical health. We discuss potential universal, selective and indicated primary prevention strategies for inflammation-related depression. We consider potential approaches to secondary prevention, including scope for anti-inflammatory treatment and CRP testing for guiding treatment allocation and prognosis. Preventive strategies discussed here could also be relevant for other inflammation-mediated mental health conditions.v

AB - The multifaceted role of low-grade systemic inflammation in depression and physical illnesses like cardiovascular disease highlights complex interactions between the body, brain and mind. While current research on inflammation and depression has largely focused on exploring possible disease mechanisms and therapeutic potential, we seek to broaden the current discussion by introducing a public health perspective. In this Viewpoint, we propose that inflammation and its contributing sources could represent important targets for public health strategies aimed at improving both mental and physical health. We discuss potential universal, selective and indicated primary prevention strategies for inflammation-related depression. We consider potential approaches to secondary prevention, including scope for anti-inflammatory treatment and CRP testing for guiding treatment allocation and prognosis. Preventive strategies discussed here could also be relevant for other inflammation-mediated mental health conditions.v

KW - Mental Health

KW - Depression

KW - Immunopsychiatry

KW - Inflammation

KW - Public Health

KW - Prevention

U2 - 10.1016/j.bbi.2021.04.015

DO - 10.1016/j.bbi.2021.04.015

M3 - Editorial (Academic Journal)

C2 - 33882327

SN - 0889-1591

VL - 95

SP - 1

EP - 3

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

ER -

Inflammation and Depression: A Public Health Perspective

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Projects

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

Cite this