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Inflammatory pathways are central to posterior cerebrovascular artery remodelling prior to the onset of congenital hypertension

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1803-1817
Number of pages15
JournalJournal of Cerebral Blood Flow and Metabolism
Volume39
Early online date13 Apr 2018
DOIs
DateAccepted/In press - 20 Feb 2018
DateE-pub ahead of print - 13 Apr 2018
DatePublished (current) - 1 Sep 2019

Abstract

Cerebral artery hypoperfusion may provide the basis for linking ischemic stroke with hypertension. Brain hypoperfusion may induce hypertension that may serve as an auto-protective mechanism to prevent ischemic stroke. We hypothesised that hypertension is caused by remodelling of the cerebral arteries, which is triggered by inflammation. We used a congenital rat model of hypertension and examined age-related changes in gene expression of the cerebral arteries using RNA sequencing. Prior to hypertension, we found changes in signalling pathways associated with the immune system and fibrosis. Validation studies using second harmonics generation microscopy revealed upregulation of collagen type I and IV in both tunica externa and media. These changes in the extracellular matrix of cerebral arteries pre-empted hypertension accounting for their increased stiffness and resistance, both potentially conducive to stroke. These data indicate that inflammatory driven cerebral artery remodelling occurs prior to the onset of hypertension and may be a trigger elevating systemic blood pressure in genetically programmed hypertension.

    Research areas

  • Cerebrovascular remodelling, transcriptomic plasticity, genetic hypertension, inflammatory pathways, fluorescent microscopy

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via SAGE at http://journals.sagepub.com/doi/10.1177/0271678X18769180. Please refer to any applicable terms of use of the publisher.

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