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Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Research output: Contribution to journalArticle

  • Paula Jakszyn
  • Valerie Cayssials
  • Genevieve Buckland
  • Aurora Perez-Cornago
  • Elisabete Weiderpass
  • Heiner Boeing
  • Manuela M Bergmann
  • Alexandra Vulcan
  • Bodil Ohlsson
  • Giovanna Masala
  • Amanda J Cross
  • Elio Riboli
  • Fulvio Ricceri
  • Christina C Dahm
  • Dorthe Nyvang
  • Verena A Katzke
  • Tilman Kühn
  • Cecilie Kyrø
  • Anne Tjønneland
  • Heather A Ward
  • Konstantinos K Tsilidis
  • Guri Skeie
  • Sabina Sieri
  • Maria-Jose Sanchez
  • Jose M Huerta
  • Pilar Amiano
  • Cristina Lasheras
  • Eva Ardanaz
  • Yahya Mahamat-Saleh
  • Marie-Christine Boutron-Ruault
  • Franck Carbonnel
  • Salvatore Panico
  • Eleni Peppa
  • Antonia Trichopoulou
  • Anna Karakatsani
  • Rosario Tumino
  • Roel Vermeulen
  • Mazda Jenab
  • Marc Gunter
  • Antonio Agudo
Original languageEnglish
Number of pages14
JournalInternational Journal of Cancer
Early online date16 Jan 2020
DOIs
DateAccepted/In press - 12 Dec 2019
DateE-pub ahead of print (current) - 16 Jan 2020

Abstract

Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31-2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.

    Research areas

  • inflammatory potential of the diet, colorectal cancer, prospective cohort, Europe, epidemiology, Association

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32870. Please refer to any applicable terms of use of the publisher

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  • Supplementary information 1 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32870. Please refer to any applicable terms of use of the publisher

    Accepted author manuscript, 373 KB, PDF document

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  • Supplementary information 2 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32870. Please refer to any applicable terms of use of the publisher

    Accepted author manuscript, 146 KB, PDF document

    Embargo ends: 16/01/21

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