Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Juliette Fremaux; Christel Dolain; Brice Kauffmann; Jonathan Clayden; Gilles Guichard

doi:10.1039/c3cc40961a

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Juliette Fremaux, Christel Dolain, Brice Kauffmann, Jonathan Clayden^*, Gilles Guichard

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

Abstract

The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

Original language	English
Pages (from-to)	7415-7417
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	67
Early online date	21 Jun 2013
DOIs	https://doi.org/10.1039/c3cc40961a
Publication status	Published - 28 Aug 2013

Access to Document

10.1039/c3cc40961a

Cite this

@article{f4f2763ace4749c58888e3e6f8d1a2c3,

title = "Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers",

abstract = "The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.",

author = "Juliette Fremaux and Christel Dolain and Brice Kauffmann and Jonathan Clayden and Gilles Guichard",

year = "2013",

month = aug,

day = "28",

doi = "10.1039/c3cc40961a",

language = "English",

volume = "49",

pages = "7415--7417",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "67",

}

TY - JOUR

T1 - Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

AU - Fremaux, Juliette

AU - Dolain, Christel

AU - Kauffmann, Brice

AU - Clayden, Jonathan

AU - Guichard, Gilles

PY - 2013/8/28

Y1 - 2013/8/28

N2 - The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

AB - The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

UR - http://www.scopus.com/inward/record.url?scp=84883474866&partnerID=8YFLogxK

U2 - 10.1039/c3cc40961a

DO - 10.1039/c3cc40961a

M3 - Article (Academic Journal)

C2 - 23862177

AN - SCOPUS:84883474866

VL - 49

SP - 7415

EP - 7417

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 67

ER -

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Abstract

Access to Document

Other files and links

Fingerprint

Cite this