Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Juliette Fremaux; Christel Dolain; Brice Kauffmann; Jonathan Clayden; Gilles Guichard

doi:10.1039/c3cc40961a

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Juliette Fremaux, Christel Dolain, Brice Kauffmann, Jonathan Clayden^*, Gilles Guichard

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

15 Citations (Scopus)

Abstract

The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

Original language	English
Pages (from-to)	7415-7417
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	67
Early online date	21 Jun 2013
DOIs	https://doi.org/10.1039/c3cc40961a
Publication status	Published - 28 Aug 2013

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abstract = "The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.",

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AU - Fremaux, Juliette

AU - Dolain, Christel

AU - Kauffmann, Brice

AU - Clayden, Jonathan

AU - Guichard, Gilles

PY - 2013/8/28

Y1 - 2013/8/28

N2 - The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

AB - The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

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U2 - 10.1039/c3cc40961a

DO - 10.1039/c3cc40961a

M3 - Article (Academic Journal)

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Abstract

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