Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Juliette Fremaux, Christel Dolain, Brice Kauffmann, Jonathan Clayden*, Gilles Guichard

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

Original languageEnglish
Pages (from-to)7415-7417
Number of pages3
JournalChemical Communications
Volume49
Issue number67
Early online date21 Jun 2013
DOIs
Publication statusPublished - 28 Aug 2013

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