Influenza and RSV make a modest contribution to invasive pneumococcal disease incidence in the UK

Emily J Agnew, Caroline L. Trotter, Katherine M. E. Turner, Caroline Colijn, Pauline Waight, Elizabeth Miller

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

Objectives: The common seasonality of incidence of invasive pneumococcal disease (IPD) and viral respiratory infections has long been recognized, however, the extent to which this affects the association between the pathogens is unknown. We have analysed weekly surveillance data of IPD, influenza and respiratory syncytial virus (RSV), using ambient temperature and hours of sunshine as measures of seasonality.

Methods: Reported cases of influenza, IPD and RSV, were collected in England and Wales, from week 1 (January) 1996 to week 23 (June) 2009. The associations between IPD and respiratory viral infections were analysed using several statistical methods, including correlation coefficients and both additive and multiplicative regression models.

Results: 6-7.5% of cases of IPD are attributable to influenza and 3-4% attributable to RSV. Correlation coefficients reported considerably stronger associations between IPD and the viral infections compared to regression models.

Conclusions: A small but potentially important percentage of IPD may be attributable to influenza and RSV when adjusted for seasonality by temperature. Jointly these viral infections may lead to over 10% of IPD cases. Therefore, prevention of viral respiratory infections may offer some additional benefit in reducing invasive pneumococcal infections. (C) 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalJournal of Infection
Volume66
Issue number6
DOIs
Publication statusPublished - Jun 2013

Bibliographical note

Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Keywords

  • Invasive pneumococcal disease
  • Influenza
  • Respiratory syncytial virus
  • Seasonality
  • RESPIRATORY SYNCYTIAL VIRUS
  • STREPTOCOCCUS-PNEUMONIAE
  • INFECTIOUS-DISEASES
  • VITAMIN-D
  • ASSOCIATION
  • SEASONALITY
  • ADHERENCE
  • TEMPERATURE
  • EPITHELIUM
  • EPIDEMIC

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