Inhibition of Na+-Ca2+ exchange mechanism in cardiac sarcolemmal vesicles by harmaline

M S Suleiman, J P Reeves

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

1. Harmaline was found to inhibit the Na+-Ca2+ exchange mechanism present in cardiac sarcolemmal vesicles. 2. The inhibition was dose-dependent and was observed in the range 10(-5) M-10(-2) M harmaline. 3. The effect was demonstrated on both 45Ca2+-uptake and 45Ca2+-efflux. 4. The observed Ki value for harmaline inhibition of 45Ca2+-uptake was found to be 2.5 X 10(-4) M.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalComparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology
Volume88
Issue number1
Publication statusPublished - 1987

Keywords

  • Alkaloids
  • Animals
  • Calcium
  • Calcium Radioisotopes
  • Carrier Proteins
  • Cattle
  • Harmaline
  • Kinetics
  • Myocardium
  • Sarcolemma
  • Sodium-Calcium Exchanger
  • Journal Article

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