1. Harmaline was found to inhibit the Na+-Ca2+ exchange mechanism present in cardiac sarcolemmal vesicles. 2. The inhibition was dose-dependent and was observed in the range 10(-5) M-10(-2) M harmaline. 3. The effect was demonstrated on both 45Ca2+-uptake and 45Ca2+-efflux. 4. The observed Ki value for harmaline inhibition of 45Ca2+-uptake was found to be 2.5 X 10(-4) M.
|Number of pages||4|
|Journal||Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology|
|Publication status||Published - 1987|
- Calcium Radioisotopes
- Carrier Proteins
- Sodium-Calcium Exchanger
- Journal Article