Abstract
1. Harmaline was found to inhibit the Na+-Ca2+ exchange mechanism present in cardiac sarcolemmal vesicles. 2. The inhibition was dose-dependent and was observed in the range 10(-5) M-10(-2) M harmaline. 3. The effect was demonstrated on both 45Ca2+-uptake and 45Ca2+-efflux. 4. The observed Ki value for harmaline inhibition of 45Ca2+-uptake was found to be 2.5 X 10(-4) M.
| Original language | English |
|---|---|
| Pages (from-to) | 197-200 |
| Number of pages | 4 |
| Journal | Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology |
| Volume | 88 |
| Issue number | 1 |
| Publication status | Published - 1987 |
Keywords
- Alkaloids
- Animals
- Calcium
- Calcium Radioisotopes
- Carrier Proteins
- Cattle
- Harmaline
- Kinetics
- Myocardium
- Sarcolemma
- Sodium-Calcium Exchanger
- Journal Article
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