Inhibition of the cardiac L-type calcium channel current by the trpm8 agonist, (-)-menthol

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Abstract

(-)-Menthol and icilin are agonists of the thermoreceptor non-selective cation channel, TRPM8, and are commonly used to investigate TRPM8 function without a full appreciation of their non-specific effects. To investigate the hypothesis that (-)-menthol and icilin inhibit cardiovascular-type L-type Ca(2+) channel currents (I(Ca,L)), the actions of the TRPM8 agonists on rabbit ventricular myocyte I(Ca,L) were examined at near-physiological temperature (≈35°C) using whole-cell recording. Icilin (3-100 μM) did not significantly inhibit I(Ca,L). (3) in contrast, (-)-menthol concentration-dependently inhibited peak I(Ca,L) (IC(50)=74.6 μM; log(10)IC(50)(M)=-4.13±0.14). (-)-Menthol blocked the late I(Ca,L) remaining at the end of depolarising pulses with greater efficacy (96.1±2.4% block at 1 mM) than peak I(Ca,L) (68.9±5.7% block at 1 mM, P
Translated title of the contributionInhibition of the cardiac L-type calcium channel current by the trpm8 agonist, (-)-menthol
Original languageEnglish
Pages (from-to)543 - 550
Number of pages8
JournalJournal of Physiology and Pharmacology
Volume61
DOIs
Publication statusPublished - Oct 2010

Bibliographical note

Publisher: Polish Physiological Society

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