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Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms

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Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms. / Philip, Nebu; Bandara, H. M.H.N.; Leishman, Shaneen J.; Walsh, Laurence J.

In: European Journal of Oral Sciences, 28.12.2018.

Research output: Contribution to journalArticle

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APA

Philip, N., Bandara, H. M. H. N., Leishman, S. J., & Walsh, L. J. (2018). Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms. European Journal of Oral Sciences. https://doi.org/10.1111/eos.12602

Vancouver

Philip N, Bandara HMHN, Leishman SJ, Walsh LJ. Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms. European Journal of Oral Sciences. 2018 Dec 28. https://doi.org/10.1111/eos.12602

Author

Philip, Nebu ; Bandara, H. M.H.N. ; Leishman, Shaneen J. ; Walsh, Laurence J. / Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms. In: European Journal of Oral Sciences. 2018.

Bibtex

@article{2aa65bb9c8f94e05b9edc7ce72d56a4e,
title = "Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms",
abstract = "Dark-colored fruit berries are a rich source of polyphenols that could provide innovative bioactive molecules as natural weapons against dental caries. High-quality extracts of cranberry, blueberry, and strawberry, and a combination of the three berry extracts (Orophenol), were used to treat 24-h-old Streptococcus mutans biofilms. The grown biofilms were treated with the berry extracts at concentrations ranging from 62.5 to 500 μg ml−1. Treated biofilms were assessed for metabolic activity, acidogenicity, biovolumes, structural organization, and bacterial viability. The biofilms treated with the cranberry and Orophenol extracts exhibited the most significant reductions in metabolic activity, acid production, and bacterial/exopolysaccharide (EPS) biovolumes, while their structural architecture appeared less compact than the control-treated biofilms. The blueberry extract produced significant reductions in metabolic activity and acidogenicity only at the highest concentration tested, without significantly affecting bacterial/EPS biovolumes or biofilm architecture. Strawberry extracts had no significant effects on S. mutans biofilms. None of the berry extracts were bactericidal for S. mutans. The results indicate that cranberry extract was the most effective extract in disrupting S. mutans virulence properties without significantly affecting bacterial viability. This suggests a potential ecological role for cranberry phenols as non-bactericidal agents capable of modulating pathogenicity of cariogenic biofilms.",
keywords = "biofilm ecology, dental caries, natural products",
author = "Nebu Philip and Bandara, {H. M.H.N.} and Leishman, {Shaneen J.} and Walsh, {Laurence J.}",
year = "2018",
month = "12",
day = "28",
doi = "10.1111/eos.12602",
language = "English",
journal = "European Journal of Oral Sciences",
issn = "0909-8836",
publisher = "Munksgaard International Publishers",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms

AU - Philip, Nebu

AU - Bandara, H. M.H.N.

AU - Leishman, Shaneen J.

AU - Walsh, Laurence J.

PY - 2018/12/28

Y1 - 2018/12/28

N2 - Dark-colored fruit berries are a rich source of polyphenols that could provide innovative bioactive molecules as natural weapons against dental caries. High-quality extracts of cranberry, blueberry, and strawberry, and a combination of the three berry extracts (Orophenol), were used to treat 24-h-old Streptococcus mutans biofilms. The grown biofilms were treated with the berry extracts at concentrations ranging from 62.5 to 500 μg ml−1. Treated biofilms were assessed for metabolic activity, acidogenicity, biovolumes, structural organization, and bacterial viability. The biofilms treated with the cranberry and Orophenol extracts exhibited the most significant reductions in metabolic activity, acid production, and bacterial/exopolysaccharide (EPS) biovolumes, while their structural architecture appeared less compact than the control-treated biofilms. The blueberry extract produced significant reductions in metabolic activity and acidogenicity only at the highest concentration tested, without significantly affecting bacterial/EPS biovolumes or biofilm architecture. Strawberry extracts had no significant effects on S. mutans biofilms. None of the berry extracts were bactericidal for S. mutans. The results indicate that cranberry extract was the most effective extract in disrupting S. mutans virulence properties without significantly affecting bacterial viability. This suggests a potential ecological role for cranberry phenols as non-bactericidal agents capable of modulating pathogenicity of cariogenic biofilms.

AB - Dark-colored fruit berries are a rich source of polyphenols that could provide innovative bioactive molecules as natural weapons against dental caries. High-quality extracts of cranberry, blueberry, and strawberry, and a combination of the three berry extracts (Orophenol), were used to treat 24-h-old Streptococcus mutans biofilms. The grown biofilms were treated with the berry extracts at concentrations ranging from 62.5 to 500 μg ml−1. Treated biofilms were assessed for metabolic activity, acidogenicity, biovolumes, structural organization, and bacterial viability. The biofilms treated with the cranberry and Orophenol extracts exhibited the most significant reductions in metabolic activity, acid production, and bacterial/exopolysaccharide (EPS) biovolumes, while their structural architecture appeared less compact than the control-treated biofilms. The blueberry extract produced significant reductions in metabolic activity and acidogenicity only at the highest concentration tested, without significantly affecting bacterial/EPS biovolumes or biofilm architecture. Strawberry extracts had no significant effects on S. mutans biofilms. None of the berry extracts were bactericidal for S. mutans. The results indicate that cranberry extract was the most effective extract in disrupting S. mutans virulence properties without significantly affecting bacterial viability. This suggests a potential ecological role for cranberry phenols as non-bactericidal agents capable of modulating pathogenicity of cariogenic biofilms.

KW - biofilm ecology

KW - dental caries

KW - natural products

UR - http://www.scopus.com/inward/record.url?scp=85059273406&partnerID=8YFLogxK

U2 - 10.1111/eos.12602

DO - 10.1111/eos.12602

M3 - Article

JO - European Journal of Oral Sciences

JF - European Journal of Oral Sciences

SN - 0909-8836

ER -