Innocent until proven guilty: Mechanisms and roles of Streptococcus-Candida interactions in oral health and disease

H. Xu, H. F. Jenkinson, A. Dongari-Bagtzoglou*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

72 Citations (Scopus)


Candida albicans and streptococci of the mitis group colonize the oral cavities of the majority of healthy humans. While C. albicans is considered an opportunistic pathogen, streptococci of this group are broadly considered avirulent or even beneficial organisms. However, recent evidence suggests that multi-species biofilms with these organisms may play detrimental roles in host homeostasis and may promote infection. In this review we summarize the literature on molecular interactions between members of this streptococcal group and C. albicans, with emphasis on their potential role in the pathogenesis of opportunistic oral mucosal infections.

Original languageEnglish
Pages (from-to)99-116
Number of pages8
JournalMolecular Oral Microbiology
Publication statusPublished - 2014


  • Fungal-bacterial interactions
  • Microbial synergy
  • Mucosal infection
  • Polymicrobial biofilms


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