TY - JOUR
T1 - Innocent until proven guilty
T2 - Mechanisms and roles of Streptococcus-Candida interactions in oral health and disease
AU - Xu, H.
AU - Jenkinson, H. F.
AU - Dongari-Bagtzoglou, A.
PY - 2014
Y1 - 2014
N2 - Candida albicans and streptococci of the mitis group colonize the oral cavities of the majority of healthy humans. While C. albicans is considered an opportunistic pathogen, streptococci of this group are broadly considered avirulent or even beneficial organisms. However, recent evidence suggests that multi-species biofilms with these organisms may play detrimental roles in host homeostasis and may promote infection. In this review we summarize the literature on molecular interactions between members of this streptococcal group and C. albicans, with emphasis on their potential role in the pathogenesis of opportunistic oral mucosal infections.
AB - Candida albicans and streptococci of the mitis group colonize the oral cavities of the majority of healthy humans. While C. albicans is considered an opportunistic pathogen, streptococci of this group are broadly considered avirulent or even beneficial organisms. However, recent evidence suggests that multi-species biofilms with these organisms may play detrimental roles in host homeostasis and may promote infection. In this review we summarize the literature on molecular interactions between members of this streptococcal group and C. albicans, with emphasis on their potential role in the pathogenesis of opportunistic oral mucosal infections.
KW - Fungal-bacterial interactions
KW - Microbial synergy
KW - Mucosal infection
KW - Polymicrobial biofilms
UR - http://www.scopus.com/inward/record.url?scp=84899480651&partnerID=8YFLogxK
U2 - 10.1111/omi.12049
DO - 10.1111/omi.12049
M3 - Article (Academic Journal)
C2 - 24877244
AN - SCOPUS:84899480651
VL - 29
SP - 99
EP - 116
JO - Molecular Oral Microbiology
JF - Molecular Oral Microbiology
SN - 2041-1006
ER -