Inside cover: The synthesis of highly active iridium(I) complexes and their application in catalytic hydrogen isotope exchange (Adv. Synth. Catal. 17/2014)

Jack A. Brown, Alison Ruth Cochrane, Stephanie Irvine, William Kerr, Bhaskar Mondal, John Parkinson, Laura C. Paterson, Marc Reid, Tell Tuttle, Shalini Andersson, Göran N. Nilsson

Research output: Contribution to journalArticle (Academic Journal)peer-review


The inside cover picture, by Kerr and co-workers depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N-heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts’ utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies.
Original languageUndefined/Unknown
JournalAdvanced Synthesis and Catalysis
Publication statusPublished - 24 Nov 2014

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