Insulin and growth factors adaptation to normal puberty

M O Savage, C P Smith, D B Dunger, E A Gale, J M Holly, M A Preece

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)


Insulin and IGF-1 production were measured throughout childhood and puberty and into adult life. Basal insulin and IGF-1 secretion increased during puberty, falling back to prepubertal levels in adulthood. However, fasting glucose levels remained constant, implying an increase in tissue resistance to insulin coinciding with puberty.
Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalHormone Research
Issue numberSuppl 3
Publication statusPublished - 1992


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