Insulin-like growth factor binding protein 1 response to acute insulin induced hypoglycaemia in type 1 diabetes

J D Quin, B M Fisher, A C MacCuish, G H Beastall, M Small, J M Holly, A M Cotterill

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)

Abstract

Insulin is believed to be the prime regulator of insulin-like growth factor binding protein 1 (IGFBP-1) secretion, and in normal subjects acute insulin induced hypoglycaemia exerts a rapid effect on concentrations of IGFBP-1, and may also influence insulin-like growth factor I (IGF-I) concentrations. The rise in IGFBP-1 concentrations in normal subjects following hypoglycaemia has been suggested to be due to suppression of endogenous insulin secretion. We have examined this further by studying diabetics with no endogenous insulin secretion.
Original languageEnglish
Pages (from-to)225-9
Number of pages5
JournalClinical Endocrinology
Volume41
Issue number2
Publication statusPublished - 1994

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