Insulin-like growth factor binding protein 1 response to acute insulin induced hypoglycaemia in type 1 diabetes

J D Quin; B M Fisher; A C MacCuish; G H Beastall; M Small; J M Holly; A M Cotterill

Insulin-like growth factor binding protein 1 response to acute insulin induced hypoglycaemia in type 1 diabetes

J D Quin
, B M Fisher
, A C MacCuish
, G H Beastall
, M Small
, J M Holly
, A M Cotterill

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

5 Citations (Scopus)

Abstract

Insulin is believed to be the prime regulator of insulin-like growth factor binding protein 1 (IGFBP-1) secretion, and in normal subjects acute insulin induced hypoglycaemia exerts a rapid effect on concentrations of IGFBP-1, and may also influence insulin-like growth factor I (IGF-I) concentrations. The rise in IGFBP-1 concentrations in normal subjects following hypoglycaemia has been suggested to be due to suppression of endogenous insulin secretion. We have examined this further by studying diabetics with no endogenous insulin secretion.

Original language	English
Pages (from-to)	225-9
Number of pages	5
Journal	Clinical Endocrinology
Volume	41
Issue number	2
Publication status	Published - 1994

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title = "Insulin-like growth factor binding protein 1 response to acute insulin induced hypoglycaemia in type 1 diabetes",

abstract = "Insulin is believed to be the prime regulator of insulin-like growth factor binding protein 1 (IGFBP-1) secretion, and in normal subjects acute insulin induced hypoglycaemia exerts a rapid effect on concentrations of IGFBP-1, and may also influence insulin-like growth factor I (IGF-I) concentrations. The rise in IGFBP-1 concentrations in normal subjects following hypoglycaemia has been suggested to be due to suppression of endogenous insulin secretion. We have examined this further by studying diabetics with no endogenous insulin secretion.",

author = "Quin, \{J D\} and Fisher, \{B M\} and MacCuish, \{A C\} and Beastall, \{G H\} and M Small and Holly, \{J M\} and Cotterill, \{A M\}",

year = "1994",

language = "English",

volume = "41",

pages = "225--9",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Insulin-like growth factor binding protein 1 response to acute insulin induced hypoglycaemia in type 1 diabetes

AU - Quin, J D

AU - Fisher, B M

AU - MacCuish, A C

AU - Beastall, G H

AU - Small, M

AU - Holly, J M

AU - Cotterill, A M

PY - 1994

Y1 - 1994

N2 - Insulin is believed to be the prime regulator of insulin-like growth factor binding protein 1 (IGFBP-1) secretion, and in normal subjects acute insulin induced hypoglycaemia exerts a rapid effect on concentrations of IGFBP-1, and may also influence insulin-like growth factor I (IGF-I) concentrations. The rise in IGFBP-1 concentrations in normal subjects following hypoglycaemia has been suggested to be due to suppression of endogenous insulin secretion. We have examined this further by studying diabetics with no endogenous insulin secretion.

AB - Insulin is believed to be the prime regulator of insulin-like growth factor binding protein 1 (IGFBP-1) secretion, and in normal subjects acute insulin induced hypoglycaemia exerts a rapid effect on concentrations of IGFBP-1, and may also influence insulin-like growth factor I (IGF-I) concentrations. The rise in IGFBP-1 concentrations in normal subjects following hypoglycaemia has been suggested to be due to suppression of endogenous insulin secretion. We have examined this further by studying diabetics with no endogenous insulin secretion.

M3 - Article (Academic Journal)

C2 - 7523002

SN - 0300-0664

VL - 41

SP - 225

EP - 229

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 2

ER -

Insulin-like growth factor binding protein 1 response to acute insulin induced hypoglycaemia in type 1 diabetes

Abstract

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