Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years

Imogen Rogers; Chris Metcalfe; David Gunnell; Pauline Emmett; David Dunger; Jeffrey M P Holly; ALSPAC Study Team

doi:10.1210/jc.2006-0388

Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years

Imogen Rogers, Chris Metcalfe, David Gunnell, Pauline Emmett, David Dunger, Jeffrey M P Holly, ALSPAC Study Team

Research output: Contribution to journal › Article (Academic Journal) › peer-review

86 Citations (Scopus)

Abstract

IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7-8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9-10 yr.

Translated title of the contribution	Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years
Original language	English
Pages (from-to)	2514 - 2519
Number of pages	6
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	91
Issue number	7
DOIs	https://doi.org/10.1210/jc.2006-0388
Publication status	Published - Jul 2006

Bibliographical note

Publisher: Endocrine Society

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://jcem.endojournals.org/cgi/content/abstract/91/7/2514

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EXTENSION OF RD1321 VIA IOP.
Golding, J. (Principal Investigator)
1/02/01 → 1/02/06
Project: Research

Cite this

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title = "Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years",

abstract = "IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7-8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9-10 yr.",

author = "Imogen Rogers and Chris Metcalfe and David Gunnell and Pauline Emmett and David Dunger and Holly, {Jeffrey M P} and {ALSPAC Study Team}",

note = "Publisher: Endocrine Society",

year = "2006",

month = jul,

doi = "10.1210/jc.2006-0388",

language = "English",

volume = "91",

pages = "2514 -- 2519",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "1945-7197",

publisher = "Oxford University Press",

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}

TY - JOUR

T1 - Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years

AU - Rogers, Imogen

AU - Metcalfe, Chris

AU - Gunnell, David

AU - Emmett, Pauline

AU - Dunger, David

AU - Holly, Jeffrey M P

AU - ALSPAC Study Team

N1 - Publisher: Endocrine Society

PY - 2006/7

Y1 - 2006/7

N2 - IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7-8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9-10 yr.

AB - IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7-8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9-10 yr.

U2 - 10.1210/jc.2006-0388

DO - 10.1210/jc.2006-0388

M3 - Article (Academic Journal)

C2 - 16670160

SN - 1945-7197

VL - 91

SP - 2514

EP - 2519

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 7

ER -

Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years

Abstract

Bibliographical note

UN SDGs

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EXTENSION OF RD1321 VIA IOP.

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