Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years

Imogen Rogers, Chris Metcalfe, David Gunnell, Pauline Emmett, David Dunger, Jeffrey M P Holly, ALSPAC Study Team

Research output: Contribution to journalArticle (Academic Journal)peer-review

70 Citations (Scopus)

Abstract

IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7-8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9-10 yr.
Translated title of the contributionInsulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years
Original languageEnglish
Pages (from-to)2514 - 2519
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number7
DOIs
Publication statusPublished - Jul 2006

Bibliographical note

Publisher: Endocrine Society

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