Insulin-like growth factor ligands, receptors and binding proteins in cancer

EJ Foulstone; SN Prince; OJ Zaccheo; JL Burns; JA Harper; CI Jacobs; D Church; AB Hassan

doi:10.1002/path.1712

Insulin-like growth factor ligands, receptors and binding proteins in cancer

EJ Foulstone, SN Prince, OJ Zaccheo, JL Burns, JA Harper, CI Jacobs, D Church, AB Hassan

Research output: Contribution to journal › Article (Academic Journal) › peer-review

222 Citations (Scopus)

Abstract

This review aims to summarize experimental evidence supporting the role of the insulin-like growth factor (IGF) signalling system in the progression, maintenance, and treatment of cancer. These data implicate the IGF system as an important modifier of cancer cell proliferation, survival, growth, and treatment sensitivity. The role of the IGF system in cancer should be examined in the context of the extra-cellular and intra-cellular signalling networks, in particular: phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt/PKB), mammalian target of rapamycin (mTOR), and forkhead transcription factors (FOXO). This review highlights evidence derived from molecular structure and functional genetics with respect to how the extra-cellular components of the IGF system function normally, and their subsequent modifications in cancer. The therapeutic relevance of the research evidence described is also addressed, as the challenge is to apply this knowledge to human health.

Translated title of the contribution	Insulin-like growth factor ligands, receptors and binding proteins in cancer
Original language	English
Pages (from-to)	145 - 153
Number of pages	8
Journal	Journal of Pathology
Volume	205
DOIs	https://doi.org/10.1002/path.1712
Publication status	Published - Jan 2005

Bibliographical note

Publisher: Wiley
Other: Review. Most accessed article for J Pathology in 2005

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title = "Insulin-like growth factor ligands, receptors and binding proteins in cancer",

abstract = "This review aims to summarize experimental evidence supporting the role of the insulin-like growth factor (IGF) signalling system in the progression, maintenance, and treatment of cancer. These data implicate the IGF system as an important modifier of cancer cell proliferation, survival, growth, and treatment sensitivity. The role of the IGF system in cancer should be examined in the context of the extra-cellular and intra-cellular signalling networks, in particular: phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt/PKB), mammalian target of rapamycin (mTOR), and forkhead transcription factors (FOXO). This review highlights evidence derived from molecular structure and functional genetics with respect to how the extra-cellular components of the IGF system function normally, and their subsequent modifications in cancer. The therapeutic relevance of the research evidence described is also addressed, as the challenge is to apply this knowledge to human health.",

author = "EJ Foulstone and SN Prince and OJ Zaccheo and JL Burns and JA Harper and CI Jacobs and D Church and AB Hassan",

note = "Publisher: Wiley Other: Review. Most accessed article for J Pathology in 2005",

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doi = "10.1002/path.1712",

language = "English",

volume = "205",

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T1 - Insulin-like growth factor ligands, receptors and binding proteins in cancer

AU - Foulstone, EJ

AU - Prince, SN

AU - Zaccheo, OJ

AU - Burns, JL

AU - Harper, JA

AU - Jacobs, CI

AU - Church, D

AU - Hassan, AB

N1 - Publisher: Wiley Other: Review. Most accessed article for J Pathology in 2005

PY - 2005/1

Y1 - 2005/1

N2 - This review aims to summarize experimental evidence supporting the role of the insulin-like growth factor (IGF) signalling system in the progression, maintenance, and treatment of cancer. These data implicate the IGF system as an important modifier of cancer cell proliferation, survival, growth, and treatment sensitivity. The role of the IGF system in cancer should be examined in the context of the extra-cellular and intra-cellular signalling networks, in particular: phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt/PKB), mammalian target of rapamycin (mTOR), and forkhead transcription factors (FOXO). This review highlights evidence derived from molecular structure and functional genetics with respect to how the extra-cellular components of the IGF system function normally, and their subsequent modifications in cancer. The therapeutic relevance of the research evidence described is also addressed, as the challenge is to apply this knowledge to human health.

AB - This review aims to summarize experimental evidence supporting the role of the insulin-like growth factor (IGF) signalling system in the progression, maintenance, and treatment of cancer. These data implicate the IGF system as an important modifier of cancer cell proliferation, survival, growth, and treatment sensitivity. The role of the IGF system in cancer should be examined in the context of the extra-cellular and intra-cellular signalling networks, in particular: phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt/PKB), mammalian target of rapamycin (mTOR), and forkhead transcription factors (FOXO). This review highlights evidence derived from molecular structure and functional genetics with respect to how the extra-cellular components of the IGF system function normally, and their subsequent modifications in cancer. The therapeutic relevance of the research evidence described is also addressed, as the challenge is to apply this knowledge to human health.

U2 - 10.1002/path.1712

DO - 10.1002/path.1712

M3 - Article (Academic Journal)

SN - 1096-9896

VL - 205

SP - 145

EP - 153

JO - Journal of Pathology

JF - Journal of Pathology

ER -

Insulin-like growth factor ligands, receptors and binding proteins in cancer

Abstract

Bibliographical note

UN SDGs

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