We assessed the abundance of the IR isoforms both in vivo and in vitro and observed that the majority of the tissue samples and cell lines expressed more IR-A than IR-B. Alterations in the isoforms in response to changes in their hormonal milieu could have a profound impact on how malignant cells behave and play a role in promoting carcinogenesis. A greater understanding of the mechanisms underlying changes in alternative splicing of the IR may provide additional targets for future cancer therapies.
- prostate cancer
- splicing variants
- insulin receptor
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- Bristol Medical School (THS) - Associate Professor
- Insulin-like Growth Factors and Metabolic Endocrinology Group
Person: Academic , Member