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Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials

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Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials. / Richards, David A; Bazeley, Patricia; Borglin, Gunilla; Craig, Peter; Emsley, Richard; Frost, Julia ; Hill, Jacqueline; Horwood, Jeremy; Hutchings, Hayley Anne; Jinks, Clare; Montgomery, Alan; Moore, Graham; Plano Clark, Vicki L; Tonkin-Crine, Sarah; Wade, Julia; Warren, Fiona C; Wyke, Sally; Young, Bridget; O'Cathain, Alicia.

In: BMJ Open, Vol. 9, e032081, 26.11.2019.

Research output: Contribution to journalArticle

Harvard

Richards, DA, Bazeley, P, Borglin, G, Craig, P, Emsley, R, Frost, J, Hill, J, Horwood, J, Hutchings, HA, Jinks, C, Montgomery, A, Moore, G, Plano Clark, VL, Tonkin-Crine, S, Wade, J, Warren, FC, Wyke, S, Young, B & O'Cathain, A 2019, 'Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials', BMJ Open, vol. 9, e032081. https://doi.org/10.1136/bmjopen-2019-032081

APA

Richards, D. A., Bazeley, P., Borglin, G., Craig, P., Emsley, R., Frost, J., ... O'Cathain, A. (2019). Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials. BMJ Open, 9, [e032081]. https://doi.org/10.1136/bmjopen-2019-032081

Vancouver

Richards DA, Bazeley P, Borglin G, Craig P, Emsley R, Frost J et al. Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials. BMJ Open. 2019 Nov 26;9. e032081. https://doi.org/10.1136/bmjopen-2019-032081

Author

Richards, David A ; Bazeley, Patricia ; Borglin, Gunilla ; Craig, Peter ; Emsley, Richard ; Frost, Julia ; Hill, Jacqueline ; Horwood, Jeremy ; Hutchings, Hayley Anne ; Jinks, Clare ; Montgomery, Alan ; Moore, Graham ; Plano Clark, Vicki L ; Tonkin-Crine, Sarah ; Wade, Julia ; Warren, Fiona C ; Wyke, Sally ; Young, Bridget ; O'Cathain, Alicia. / Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials. In: BMJ Open. 2019 ; Vol. 9.

Bibtex

@article{a074d9cae80345e88da28cae676e9f45,
title = "Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials",
abstract = "It is common to undertake qualitative research alongside randomised controlled trials (RCTs) when evaluating complex interventions. Researchers tend to analyse these datasets separately and then consider their findings separately within the discussion section of the final report, rarely integrating quantitative and qualitative data or findings, and missing opportunities to integrate data in order to generate further important insights about the intervention under evaluation. This paper reports on a two day expert meeting funded by the United Kingdom Medical Research Council Hubs for Trials Methodology Research with the aims to identify current strengths and weaknesses in the integration of quantitative and qualitative methods in clinical trials, establish the next steps required to provide the trials community with guidance on the integration of mixed methods in RCTs and set-up a network of individuals, groups and organisations willing to collaborate on related methodological activity. We summarise integration techniques and highlight the potential value of integration using three examples. We suggest that applying mixed methods integration techniques to data or findings from studies involving both RCTs and qualitative research can yield insights that might be useful for understanding variation in outcomes, the mechanism by which interventions have an impact, and identifying ways of tailoring therapy to patient preference and type. Given a general lack of examples and knowledge of these techniques, researchers and funders will need future guidance on how to undertake and appraise them.",
keywords = "qualitative, randomised controlled trials, research methods, integration, trials, quantitative",
author = "Richards, {David A} and Patricia Bazeley and Gunilla Borglin and Peter Craig and Richard Emsley and Julia Frost and Jacqueline Hill and Jeremy Horwood and Hutchings, {Hayley Anne} and Clare Jinks and Alan Montgomery and Graham Moore and {Plano Clark}, {Vicki L} and Sarah Tonkin-Crine and Julia Wade and Warren, {Fiona C} and Sally Wyke and Bridget Young and Alicia O'Cathain",
year = "2019",
month = "11",
day = "26",
doi = "10.1136/bmjopen-2019-032081",
language = "English",
volume = "9",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Integrating quantitative and qualitative data and findings when undertaking randomised controlled trials

AU - Richards, David A

AU - Bazeley, Patricia

AU - Borglin, Gunilla

AU - Craig, Peter

AU - Emsley, Richard

AU - Frost, Julia

AU - Hill, Jacqueline

AU - Horwood, Jeremy

AU - Hutchings, Hayley Anne

AU - Jinks, Clare

AU - Montgomery, Alan

AU - Moore, Graham

AU - Plano Clark, Vicki L

AU - Tonkin-Crine, Sarah

AU - Wade, Julia

AU - Warren, Fiona C

AU - Wyke, Sally

AU - Young, Bridget

AU - O'Cathain, Alicia

PY - 2019/11/26

Y1 - 2019/11/26

N2 - It is common to undertake qualitative research alongside randomised controlled trials (RCTs) when evaluating complex interventions. Researchers tend to analyse these datasets separately and then consider their findings separately within the discussion section of the final report, rarely integrating quantitative and qualitative data or findings, and missing opportunities to integrate data in order to generate further important insights about the intervention under evaluation. This paper reports on a two day expert meeting funded by the United Kingdom Medical Research Council Hubs for Trials Methodology Research with the aims to identify current strengths and weaknesses in the integration of quantitative and qualitative methods in clinical trials, establish the next steps required to provide the trials community with guidance on the integration of mixed methods in RCTs and set-up a network of individuals, groups and organisations willing to collaborate on related methodological activity. We summarise integration techniques and highlight the potential value of integration using three examples. We suggest that applying mixed methods integration techniques to data or findings from studies involving both RCTs and qualitative research can yield insights that might be useful for understanding variation in outcomes, the mechanism by which interventions have an impact, and identifying ways of tailoring therapy to patient preference and type. Given a general lack of examples and knowledge of these techniques, researchers and funders will need future guidance on how to undertake and appraise them.

AB - It is common to undertake qualitative research alongside randomised controlled trials (RCTs) when evaluating complex interventions. Researchers tend to analyse these datasets separately and then consider their findings separately within the discussion section of the final report, rarely integrating quantitative and qualitative data or findings, and missing opportunities to integrate data in order to generate further important insights about the intervention under evaluation. This paper reports on a two day expert meeting funded by the United Kingdom Medical Research Council Hubs for Trials Methodology Research with the aims to identify current strengths and weaknesses in the integration of quantitative and qualitative methods in clinical trials, establish the next steps required to provide the trials community with guidance on the integration of mixed methods in RCTs and set-up a network of individuals, groups and organisations willing to collaborate on related methodological activity. We summarise integration techniques and highlight the potential value of integration using three examples. We suggest that applying mixed methods integration techniques to data or findings from studies involving both RCTs and qualitative research can yield insights that might be useful for understanding variation in outcomes, the mechanism by which interventions have an impact, and identifying ways of tailoring therapy to patient preference and type. Given a general lack of examples and knowledge of these techniques, researchers and funders will need future guidance on how to undertake and appraise them.

KW - qualitative

KW - randomised controlled trials

KW - research methods

KW - integration

KW - trials

KW - quantitative

U2 - 10.1136/bmjopen-2019-032081

DO - 10.1136/bmjopen-2019-032081

M3 - Article

C2 - 31772096

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

M1 - e032081

ER -