Integration of the evidence on gene-disease associations: Methods of HuGE reviews

Julian P T Higgins; Julian Little

doi:10.1093/acprof:oso/9780195398441.003.0011

Integration of the evidence on gene-disease associations: Methods of HuGE reviews

Julian P T Higgins^*, Julian Little

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

Abstract

Human Genome Epidemiology (HuGE) reviews have been a cornerstone of the efforts of the Human Genome Epidemiology Network (HuGENet) to develop an online resource to house the cumulative and changing information on epidemiologic aspects of human genes. HuGE reviews may collate evidence on population frequencies of genetic variants, genotype-phenotype associations, interactions among genes and between genes, and environmental exposures, or a combination of these. More than 70 HuGE reviews have been completed under the auspices of HuGENet, with more than 80 in preparation at the time of writing. This chapter explains what HuGE reviews aim to achieve and describes some key components of the methodology for undertaking them. The material is also directly relevant to reviews and meta-analysis of genetic association studies undertaken by groups outside of HuGENet.

Original language	English
Title of host publication	Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition
Publisher	Oxford University Press
ISBN (Print)	9780199776023, 9780195398441
DOIs	https://doi.org/10.1093/acprof:oso/9780195398441.003.0011
Publication status	Published - 1 May 2010

Keywords

Gene-disease associations
Genetic association studies
Genome-wide association studies
Huge
Hugenet

Access to Document

10.1093/acprof:oso/9780195398441.003.0011

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Integration of the evidence on gene-disease associations : Methods of HuGE reviews. / Higgins, Julian P T; Little, Julian.

Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. Oxford University Press, 2010.

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

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