Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma

X Y Goh; J R E Rees; A L Paterson; S F Chin; J C Marioni; V Save; M O'Donovan; P P Eijk; D Alderson; B Ylstra; C Caldas; R C Fitzgerald

doi:10.1136/gut.2010.234179

Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma

X Y Goh, J R E Rees, A L Paterson, S F Chin, J C Marioni, V Save, M O'Donovan, P P Eijk, D Alderson, B Ylstra, C Caldas, R C Fitzgerald

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance the understanding of OAC pathogenesis and identify groups with differential outcomes.

Original language	English
Pages (from-to)	1317-1326
Number of pages	10
Journal	Gut
Volume	60
Issue number	10
DOIs	https://doi.org/10.1136/gut.2010.234179
Publication status	Published - 2011

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Goh, X. Y., Rees, J. R. E., Paterson, A. L., Chin, S. F., Marioni, J. C., Save, V., O'Donovan, M., Eijk, P. P., Alderson, D., Ylstra, B., Caldas, C., & Fitzgerald, R. C. (2011). Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma. Gut, 60(10), 1317-1326. https://doi.org/10.1136/gut.2010.234179

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title = "Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma",

abstract = "The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance the understanding of OAC pathogenesis and identify groups with differential outcomes.",

author = "Goh, {X Y} and Rees, {J R E} and Paterson, {A L} and Chin, {S F} and Marioni, {J C} and V Save and M O'Donovan and Eijk, {P P} and D Alderson and B Ylstra and C Caldas and Fitzgerald, {R C}",

year = "2011",

doi = "10.1136/gut.2010.234179",

language = "English",

volume = "60",

pages = "1317--1326",

journal = "Gut",

issn = "0017-5749",

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Goh, XY, Rees, JRE, Paterson, AL, Chin, SF, Marioni, JC, Save, V, O'Donovan, M, Eijk, PP, Alderson, D, Ylstra, B, Caldas, C & Fitzgerald, RC 2011, 'Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma', Gut, vol. 60, no. 10, pp. 1317-1326. https://doi.org/10.1136/gut.2010.234179

TY - JOUR

T1 - Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma

AU - Goh, X Y

AU - Rees, J R E

AU - Paterson, A L

AU - Chin, S F

AU - Marioni, J C

AU - Save, V

AU - O'Donovan, M

AU - Eijk, P P

AU - Alderson, D

AU - Ylstra, B

AU - Caldas, C

AU - Fitzgerald, R C

PY - 2011

Y1 - 2011

N2 - The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance the understanding of OAC pathogenesis and identify groups with differential outcomes.

AB - The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance the understanding of OAC pathogenesis and identify groups with differential outcomes.

U2 - 10.1136/gut.2010.234179

DO - 10.1136/gut.2010.234179

M3 - Article (Academic Journal)

C2 - 21478220

SN - 0017-5749

VL - 60

SP - 1317

EP - 1326

JO - Gut

JF - Gut

IS - 10

ER -

Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma

Abstract

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