Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

Jacob P Thyssen, Tarunveer S Ahluwalia, Lavinia Paternoster, Natalia Ballardini, Anna Bergstrom, Erik Melén, Bo Lund Krogsgaard Chawes, Jakob Stokholm, JO’B Hourihane, D O'Sullivan, Peter Bager, Mads Melbye, Mariona Bustamante, Maties Torrent, Ana Esplugues, Liesbeth Duijts, Chen Hu, Niels Elbert, SGMA Pasmans, Tamar NijstenAndrea von Berg, Marie Standl, Tamara Schikowski, Gunda Herberth, Joachim Heinrich, Young-Ae Lee, Ingo Marenholz, Susanne Lau, John A Curtin, Angela Simpson, Adnan Custovic, Craig E Pennell, Carol A Wang, Patrick G Holt, Hans Bisgaard, Klaus Bønnelykke*

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)

Abstract

Atopic dermatitis (AD) is a prevalent inflammatory skin disease. Loss-of-function mutations in filaggrin gene (FLG) represent the strongest genetic risk factors for AD, being strongly associated with early disease onset and persistence into adulthood.1 The epidermis of individuals with mutations in FLG is fundamentally different from normal skin being characterized by increased penetration of allergens.2

Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG (R501X, 2282del4) on the development of early-onset AD.3 This finding was replicated for the 2282del4 FLG mutation in a Dutch cohort study, and extended to further associate with risk of allergic sensitization.4 We performed analyses in multiple birth cohorts to examine the consistency and overall strength of the previously observed interaction.
Original languageEnglish
Number of pages5
JournalAllergy
Early online date5 Feb 2020
Publication statusE-pub ahead of print - 5 Feb 2020

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    Cite this

    Thyssen, J. P., Ahluwalia, T. S., Paternoster, L., Ballardini, N., Bergstrom, A., Melén, E., Chawes, B. L. K., Stokholm, J., Hourihane, JOB., O'Sullivan, D., Bager, P., Melbye, M., Bustamante, M., Torrent, M., Esplugues, A., Duijts, L., Hu, C., Elbert, N., Pasmans, SGMA., ... Bønnelykke, K. (2020). Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis. Allergy.