Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats

Ana Seoane, Chris J Tinsley, Malcolm W Brown

Research output: Contribution to journalArticle (Academic Journal)peer-review

23 Citations (Scopus)

Abstract

The role of brain-derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolidation of long-term (24 h) but not shorter-term (20 min) recognition memory.
Original languageEnglish
Pages (from-to)121-6
Number of pages6
JournalHippocampus
Volume21
Issue number2
DOIs
Publication statusPublished - 2011

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