Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells

Maria Paula Longhi, Kate Louise Wright, Sarah Nicol Lauder, Mari Ann Nowell, Gareth Wyn Jones, Andrew James Godkin, Simon Arnett Jones, Awen Myfanwy Gallimore

Research output: Contribution to journalArticle (Academic Journal)peer-review

85 Citations (Scopus)


Currently, our understanding of mechanisms underlying cell-mediated immunity and particularly of mechanisms that promote robust T cell memory to respiratory viruses is incomplete. Interleukin (IL)-6 has recently re-emerged as an important regulator of T cell proliferation and survival. Since IL-6 is abundant following infection with influenza virus, we analyzed virus-specific T cell activity in both wild type and IL-6 deficient mice. Studies outlined herein highlight a novel role for IL-6 in the development of T cell memory to influenza virus. Specifically, we find that CD4+ but not CD8+ T cell memory is critically dependent upon IL-6. This effect of IL-6 includes its ability to suppress CD4+CD25+ regulatory T cells (Treg). We demonstrate that influenza-induced IL-6 limits the activity of virus-specific Tregs, thereby facilitating the activity of virus-specific memory CD4+ T cells. These experiments reveal a critical role for IL-6 in ensuring, within the timeframe of an acute infection with a cytopathic virus, that antigen-specific Tregs have no opportunity to down-modulate the immune response, thereby favoring pathogen clearance and survival of the host.
Original languageUndefined/Unknown
JournalPLoS Pathogens
Issue number2
Publication statusPublished - 1 Feb 2008

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