Intermediates for the synthesis of 4-substituted proline derivatives

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

chemoenzymatic synthesis of a series of 2-hydroxy-5-nitro-4-substituted esters is described that uses two biotransformations in a single-pot process in which a kinetic resolution/reduction occurs. The products are valuable intermediates for the preparation of 4-substituted prolines and 5-substituted 3-hydroxypiperidinones as illustrated by the preparation of (2R,4R)-4-methylproline and (3S,5R)-3-hydroxy-5-methylpiperidinone.
Translated title of the contributionIntermediates for the synthesis of 4-substituted proline derivatives
Original languageEnglish
Pages (from-to)539 - 542
Number of pages4
JournalSYNLETT
Volume2010 (4)
DOIs
Publication statusPublished - Mar 2010

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